Evidence map›Paper›PMID 40061532›Full record

ArticleJTCVS open2025

Association of dysautonomia with refractory ventricular tachyarrhythmia in patients requiring thoracoscopic surgical cardiac sympathetic denervation.

Andrei Gurau, Dianela Perdomo, Hamza Khan, Kelsey Melinosky, Anna Chudnovets, Jacob Blum, Mahmoud Kutmah, Victor Yang, Albert Leng, Arjun Menta and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Andrei GurauDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Dianela PerdomoDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Hamza KhanValley Health System General Surgery Residency Program, Las Vegas, Nev.
Kelsey MelinoskyDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Tex.
Anna ChudnovetsGeneral Surgery Department, Charleston Area Medical Center, Charleston, WVa.
Jacob BlumDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Mahmoud KutmahDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Victor YangDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Albert LengDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Arjun MentaDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Xiyu ZhaoDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Suguru YamauchiDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Kristen RodgersDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Kathryn EcoffDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Errol BushDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Andreas S BarthDepartment of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md.
Malcolm BrockDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Frank BosmansMolecular Physiology and Neurophysics Group, Ghent University, Ghent, East Flanders, Belgium.
Jinny S HaDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.

Funding

Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
Sodium channel mutations as a possible cause for primary dysautonomiaR01NS126398 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MALCOLM V BROCK · 2023 to 2026
$1.9M
NCI NIH HHS T32 CA126607NINDS NIH HHS R01 NS126398
6 · The paper itself

Abstract

Objective: Although cardiac sympathetic denervation (CSD) effectively manages refractory ventricular tachyarrhythmias (RVTs) in long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia, the link between dysautonomia and RVT from broader etiologies is understudied. We hypothesized that dysautonomia is linked to RVT regardless of etiology in patients requiring CSD. We aimed to determine whether these patients have a high burden of dysautonomia symptoms using the Composite Autonomic Symptom Score-31 (COMPASS-31). Methods: COMPASS-31 surveys were administered to 37 patients with RVT who underwent CSD and 37 matched healthy controls. COMPASS-31 scores were compared using Mann-Whitney Results: Common operative indications were idiopathic ventricular arrhythmias (49%) and arrhythmogenic right ventricular cardiomyopathy (30%). Patients with RVT had significantly greater COMPASS-31 scores (median 25.3) compared with control patients (median 8.6, Conclusions: Dysautonomia symptoms are significantly associated with RVT requiring CSD, regardless of underlying etiology. This association, in the context of CSD efficacy in RVT across structural and nonstructural etiologies, highlights autonomic dysfunction as a common pathophysiologic link warranting further investigation.

Indexed as

autonomic dysfunctionCOMPASS-31dysautonomiarefractory ventricular tachycardiathoracic sympathectomyventricular arrhythmias

Identifiers

PMID40061532
PMCPMC11883765

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.