ArticleHeliyon2025
Anti photoaging mechanism of a novel recombinant human fibronectin peptide (rhFNP) derived from the extracellular matrix.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Cytological Performance Evaluation of a Novel Skin-Repair Agent: Recombinant Protein Disulfide Bond Isomerase.Bioengineering (Basel, Switzerland) · 2026Article
- Role of LDHA in senescent fibroblast exosomes promoting ferroptosis via histone lactylation-mediated ACSL4 regulation in skin photoaging.Epigenetics & chromatin · 2026Article
- Anti-Photoaging Effect of Soluble Microneedles Loaded with Hydroxytyrosol.International journal of molecular sciences · 2026Article
- Fibronectin-Based Skin Care Regimens for Skin Recovery After Intense Pulsed Light Therapy: A Split-Face Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Applications of Fibronectin in Biomedicine and Cosmetics: A Review.Bioengineering (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoaging is a major cause of skin ageing. Ultraviolet radiation is a key factor in this process, as it can increase the expression of inflammatory factors, promote an inflammatory response, and disrupt the balance between extracellular matrix (ECM) synthesis and degradation, resulting in impaired skin barrier function and increased skin sensitivity. Therefore, anti-inflammation and ECM remodelling are important directions in skin anti-aging research. To simulate the ECM, we constructed a novel recombinant human fibronectin peptide (rhFNP) using synthetic biology. HaCaT, P815, and NHEK cells, Zebrafish, and a KM mouse photoaging model, along with transcriptomics analysis, were used to test rhFNP function and effects. rhFNP mediated HaCaT cell adhesion and migration (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.