ArticleCureus2025
Low Serum Levels of Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1) in Immediate Postpartum Mexican Women With Gestational Diabetes.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gestational diabetes (GD) is a multifactorial disease involving hormonal, metabolic, and inflammatory factors, among which cytokines such as interleukin-6 (IL-6), interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) play key roles in immune regulation and tissue repair during pregnancy and postpartum. The aim of this study was to compare serum IL-6, IL-18, and MCP-1 concentrations in postpartum women with and without GD and to analyze sociodemographic characteristics and pregnancy-related complications. A descriptive, prospective, cross-sectional study was conducted on 32 postpartum women (16 GD and 16 controls). Sociodemographic, clinical, and biochemical data were collected. Serum cytokine levels were measured using the bead-based LEGENDplex™ assay (Biolegend, San Diego, CA, USA). Statistical analysis was performed using GraphPad Prism v9.0 (Dotmatics, Boston, MA, USA) with significance at p < 0.05. Women with gestational diabetes showed significant differences in sociodemographic factors, including higher rates of smoking (5, 31.2%) and alcohol consumption (4, 25%). Pregnancy complications such as hypertension (2, 12.5%), premature rupture of membranes (2, 12.5%), and macrosomia (5, 31.2%) were more common in the gestational diabetes group. Serum IL-6 and MCP-1 levels were significantly reduced in the gestational diabetes group compared with the control group, while IL-18 levels were not significantly different. Postpartum women with gestational diabetes have a unique inflammatory profile characterized by reduced IL-6 and MCP-1 levels. Furthermore, differences in sociodemographic factors and increased pregnancy-related complications highlight the multifactorial nature of gestational diabetes. These findings emphasize the need for further research to understand its long-term clinical impact.
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