ArticleAmerican journal of physiology. Renal physiology2025
Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters.
Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Review
- Age-Related Adaptations in Renal Tubular Function in Female Rats.Acta physiologica (Oxford, England) · 2026Article
- Contribution of murine strain background to NabioRxiv : the preprint server for biology · 2026Article
- Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.Biology of sex differences · 2026Review
- The Na/K-ATPase α1 subunit fine-tunes platelet P2Y12 function and mediates sex dimorphism-associated thrombosis.Blood advances · 2026Article
- Vascularization and maturation of kidney organoids: a comprehensive review of technological trends and challenges.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Review
- Na/K-ATPase in the renal proximal tubule cell: classic & novel roles in sodium handling.Frontiers in physiology · 2026Review
- Diurnal function and expression of aquaporins in the mouse kidney.American journal of physiology. Renal physiology · 2025Article
- Sex Differences in the Initiation and Progression of Necroptosis Following Kidney Ischemia-Reperfusion Injury.Biomedicines · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Sex differences in renal tubular salt and water transporters, channels, claudins, and regulatory factors are evident all along the nephron. The influence of sex hormones on physiologic dimorphisms has been established in studies removing, inhibiting, or restoring sex hormones and their receptors. The influence of the sex chromosome complement (SCC, XY vs. XX) on renal transporter abundance and activity is an open question. We used the four core genotypes (FCG) mouse model (in which the testis determining SRY gene is deleted from the Y chromosome and inserted onto an autosomal chromosome) to compare abundance of more than 50 renal transporters and regulators in: FXX gonadal females, FXY gonadal females, MXX Sry males, and MXY XYSry males using semiquantitative immunoblots. In addition to establishing the significant influence of gonadal hormones, we show, for the first time, that SCC contributes to sexual dimorphisms in abundance of renal transporters including: sodium/hydrogen exchanger isoform 3 (NHE3), sodium glucose cotransporter 1 (SGLT1), sodium glucose cotransporter 2 (SGLT2), aquaporin 1 (AQP1), medullary alpha1 subunit of sodium-potassium ATPase (mNKAα1), medullary beta1 subunit of sodium-potassium ATPase (mNKAβ1), sodium-chloride cotransporter, and epithelial sodium channel (ENaC) β and -γ subunits. The findings in this FCG model analysis provide the foundation for future studies of the role of sex hormones versus chromosomes on physiologic parameters, including filtration and flow, on transporter covalent modifications, and trafficking in both health and disease.
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