Evidence map›Paper›PMID 40063067›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Compositional changes of the lung extracellular matrix in acute respiratory distress syndrome.

YiWen Fan, Jill Moser, Rianne M Jongman, Theo Borghuis, Judith M Vonk, Wim Timens, Matijs van Meurs, Janesh Pillay, Janette K Burgess

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Beyond the epithelium: multicellular niches in lung regeneration and disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

YiWen FanDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-8461-5130
Jill MoserDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-9614-2577
Rianne M JongmanDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-7521-9096
Theo BorghuisDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Judith M VonkGroningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-7531-4547
Wim TimensDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-4146-6363
Matijs van MeursDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-7745-2772
Janesh PillayDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-8037-6638
Janette K BurgessDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-9868-9966

Funding

China Scholarship Council (CSC)Dutch Research Council 015.013.010ZonMw 09032212110044ZonMw (Netherlands Organisation for Health Research and Development) ZonMw Clinical Fellowship grant 09032212110044
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is pathologically characterized by diffuse alveolar damage (DAD) and is associated with high morbidity and mortality rates. Although pulmonary injury initiates alveolar-capillary barrier damage in ARDS, remodeling of the extracellular matrix (ECM), which is pivotal for both tissue repair and organ recovery, may play a large role in persistent ARDS. This study investigated the compositional changes in the ECM in different DAD stages in ARDS. Paraffin-embedded lung sections collected during autopsy or from posttransplant lungs were obtained from patients with ARDS (

Indexed as

Extracellular MatrixLungRespiratory Distress SyndromeAdultAgedCell Adhesion MoleculesCollagen Type IIICollagen Type IVCollagen Type VIFemaleFibronectinsHumansLumicanMaleMiddle AgedCell Adhesion MoleculesCOL3A1 protein, humanCollagen Type IIICollagen Type IVCollagen Type VIFibronectinsLumicanLUM protein, humanPOSTN protein, humanacute respiratory distress syndromecollagencollagen VIdiffuse alveolar damageextracellular matrix

Identifiers

PMID40063067
PMCPMC7617883

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.