ArticleSchizophrenia bulletin2025
Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis.
Article in Schizophrenia bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe cerebellum has traditionally been associated with motor functions, but recent evidence highlights its critical role in cognitive and emotional regulation, contributing to the neuropathology of schizophrenia. Our previous data-driven research demonstrated that cerebellar-cortical functional connectivity can predict antipsychotic treatment outcomes in first-episode psychosis (FEP). The present study aimed to investigate specific cerebellar functional systems involved in treatment prediction. STUDY
designThis study included 127 patients with FEP who underwent 12 weeks of antipsychotic monotherapy (either risperidone or aripiprazole). Baseline resting-state functional MRI data were collected from two 3T scanners, and functional connectivity between 10 predefined cerebellar functional systems and the whole brain was analyzed. Psychotic symptom changes were measured using the Brief Psychiatric Rating Scale-Anchored version (BPRS-A). Connectivity patterns were examined in relation to treatment outcomes. STUDY
resultsHigher baseline connectivity between the cerebellar auditory system and cortical regions, including the visual cortex, dorsolateral prefrontal cortex, and the hippocampus, predicted worse treatment outcome. In contrast, stronger connectivity between cerebellar cognitive systems (default mode and frontoparietal networks) and the anterior cingulate cortex (ACC) and medial prefrontal cortex was associated with better treatment outcome. These findings were consistently present in data acquired from both scanners and both drugs.
conclusionsOur results identify specific cerebellar-cortical circuitries as prognostic biomarkers for predicting psychosis treatment outcomes, and suggest that cerebellar auditory and cognitive systems may be potential targets for future interventions aimed at improving treatment efficacy in FEP.
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