Evidence map›Paper›PMID 40065205›Full record

SynthesisBMC medical research methodology2025

Building a synthesis-ready research ecosystem: fostering collaboration and open science to accelerate biomedical translation.

Alexandra Bannach-Brown, Torsten Rackoll, Malcolm R Macleod, Sarah K McCann

Abstract readSystematic Review
In one paragraph

Synthesis in BMC medical research methodology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra Bannach-BrownQUEST Center for Responsible Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0002-3161-1395
Torsten RackollQUEST Center for Responsible Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.ORCID 0000-0003-2170-5803
Malcolm R MacleodCentre for Clinical Brain Sciences, The University of Edinburgh Medical School, Edinburgh, UK.ORCID 0000-0001-9187-9839
Sarah K McCannQUEST Center for Responsible Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany. sarah.mccann@bih-charite.de.ORCID 0000-0003-4737-2349

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review article, we provide a comprehensive overview of current practices and challenges associated with research synthesis in preclinical biomedical research. We identify critical barriers and roadblocks that impede effective identification, utilisation, and integration of research findings to inform decision making in research translation. We examine practices at each stage of the research lifecycle, including study design, conduct, and publishing, that can be optimised to facilitate the conduct of timely, accurate, and comprehensive evidence synthesis. These practices are anchored in open science and engaging with the broader research community to ensure evidence is accessible and useful to all stakeholders. We underscore the need for collective action from researchers, synthesis specialists, institutions, publishers and journals, funders, infrastructure providers, and policymakers, who all play a key role in fostering an open, robust and synthesis-ready research environment, for an accelerated trajectory towards integrated biomedical research and translation.

Indexed as

Biomedical ResearchCooperative BehaviorResearch DesignTranslational Research, BiomedicalTranslational Science, BiomedicalHumansSystematic Reviews as TopicAnimal modelsEvidence synthesisMeta-analysisOpen sciencePreclinical researchSystematic review

Identifiers

PMID40065205
PMCPMC11892198

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.