Evidence map›Paper›PMID 40065254›Full record

ArticleBMC musculoskeletal disorders2025

Expression and significance of cytokines in peripheral blood and bone microenvironment in Kummell's disease, osteoporotic vertebral compression fractures and nonosteoporotic patients.

Ziyu Li, Qixi Yao, Yuzhi Ning, Shuang Xu, Jiyuan Yan, Qing Wang, Song Wang

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Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Ziyu Li *Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China.
Qixi Yao *Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China.
Yuzhi NingDepartment of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China.
Shuang XuDepartment of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China.
Jiyuan YanDepartment of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China.
Qing WangDepartment of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China.
Song WangDepartment of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan Province, China. jasewangspine@swmu.edu.cn.

Funding

Investigator-Initiated Trials of The Affiliated Hospital of Southwest Medical University No. HR21008Sichuan Science and Technology Program No. 2022-YFS0628
6 · The paper itself

Abstract

objectiveTo analyze the expression and determine the significance of cytokines in peripheral blood and vertebral blood in the bone microenvironment of patients with osteoporotic vertebral compression fractures (OVCFs) and Kummell's disease (KD).

methodsFrom October 2022 to April 2023, 16 patients with osteoporotic vertebral compression fracture (OVCF), 14 patients with Kummell (KD) disease, and 19 patients with lumbar degenerative disease were included in the study. The patients were divided into the OVCF group, KD group and control group. The levels of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) in peripheral blood and vertebral blood in the bone microenvironment were detected by enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to determine the correlation between cytokines and the occurrence of OVCF and KD.

resultsThe levels of IL-1, IL-6, TGF-β and TNF-α in vertebral blood in the bone microenvironment of the KD group were significantly higher than those in peripheral blood (p = 0.001, p < 0.001, p = 0.017, p < 0.001). Compared with the control group, the OVCF displayed a marked increase in the expression of IL-1, IL-6, and TNF-α and a significant reduction in the expression of TGF-β (p < 0.001). In addition, compared with the vertebral blood in the bone microenvironment of the control group, the levels of IL-1, IL-6 and TNF-α in the vertebral blood in the bone microenvironment of the KD group were significantly increased (p < 0.001). and compared with the vertebral blood in the bone microenvironment of OVCF group, the levels of IL-1, IL-6 and TNF-α in the vertebral blood in the bone microenvironment of the KD group were significantly increased (p = 0.014, p = 0.020, p = 0.006). Moreover, Compared to peripheral blood, the vertebral blood within the bone microenvironment demonstrated increased area under the curve (AUC) values for the associations of IL-1, IL-6, and TNF-α with OVCF and Kummell's disease KD.

conclusionsThe expression levels of IL-1, IL-6 and TNF-α in OVCFs and KD were increased, but that of TGF-β was decreased. The levels of IL-1, IL-6 and TNF-α in the vertebral blood of KD patients were significantly increased, which can promote vertebral osteonecrosis and bone nonunion in KD patients. Alterations in the expression levels of these proinflammatory cytokines maybe demonstrate a significant correlation with the pathogenesis of OVCF and KD.

Indexed as

CytokinesFractures, CompressionOsteoporotic FracturesSpinal FracturesAgedAged, 80 and overCellular MicroenvironmentFemaleHumansInterleukin-6Lumbar VertebraeMaleMiddle AgedTransforming Growth Factor betaTumor Necrosis Factor-alphaCytokinesInterleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alphaBone microenvironmentCytokinesKummell's diseaseOsteoimmunologyOsteoporosisOsteoporotic vertebral compression fractures

Identifiers

PMID40065254
PMCPMC11892217

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.