ReviewFluids and barriers of the CNS2025
A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.
Review in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Correlation Between Outcomes of Surgical Correction of Atlantoaxial Instability in Small Dogs and Magnetic Resonance Imaging Abnormalities.Animals : an open access journal from MDPI · 2026Article
- MRI-derived three-dimensional modelling reveals cervicothoracic subarachnoid space narrowing in syringomyelia-affected cavalier king charles spaniels.BMC veterinary research · 2026Article
- Contents under pressure: vascular proliferation and gliosis in the brains of Cavalier King Charles Spaniels with syringomyelia.Frontiers in veterinary science · 2026Article
- Teaching common cognitive biases and associated errors in veterinary neurologic diagnosis using clinical vignettes: a narrative review.Frontiers in veterinary science · 2026Review
- Comparison ofMolecular therapy. Nucleic acids · 2025Article
- Prognostic value of the preoperative study of cerebrospinal fluid dynamics in Chiari malformations: a pilot study.Acta neurochirurgica · 2025Article
- Spina bifida, diplomyelia, and Chiari-like malformation in an Aberdeen Angus calf.BMC veterinary research · 2025Article
- Subcortical and white matter alterations in canine ventriculomegaly: an observational volumetric and voxel-based-morphometry study.Fluids and barriers of the CNS · 2025Article
- Case Report: 3D-CISS and PC-MRI in the diagnosis and surgical planning of hydrocephalus secondary to presumptive lateral aperture obstruction in a dog.Frontiers in veterinary science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain homeostasis by facilitating the clearance of metabolic waste and regulating intracranial pressure. Dysregulation of CSF flow can lead to conditions like syringomyelia, and hydrocephalus. This review details the anatomy of CSF flow, examining its contribution to waste clearance within the brain and spinal cord. The review integrates data from human, canine, and other mammalian studies, with a particular focus on brachycephalic dogs. Certain dog breeds exhibit a high prevalence of CSF-related conditions due to artificial selection for neotenous traits, making them valuable models for studying analogous human conditions, such as Chiari-like malformation and syringomyelia associated with craniosynostosis. This review discusses the anatomical features specific to some brachycephalic breeds and the impact of skull and cranial cervical conformation on CSF flow patterns, providing insights into the pathophysiology and potential modelling approaches for these conditions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.