ReviewOrthopedic research and reviews2025
Artificial Single-Layer, Multi-Layer, and Gradient Scaffolds for Enhancing the Healing of Tendon-to-Bone Interfaces: A Mini-Review.
Review in Orthopedic research and reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3D-printed scaffold-based strategies for enthesis regeneration: a systematic review of the literature.Frontiers in bioengineering and biotechnology · 2026Pooled it
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendon healing after ligament or tendon reconstruction remains a significant challenge. Regenerative tissue engineering, an interdisciplinary field that combines biology, materials science, and engineering, offers promising solutions. Recent developments have introduced scaffold materials designed to enhance the proliferation and differentiation of tendon-to-bone tissue cells. These scaffolds possessing three-dimensional composites of tissue cells and biomaterials, have proven effective in facilitating tendon-to-bone curing post-surgery. The successful development of the tendon-to-bone interface is a critical factor for early rehabilitation and functional recovery. In this mini-review, we present a comprehensive update on contemporary strategies for synthetic scaffold-based materials and their influence on tendon-to-bone healing. We described the synthetic materials compositions, structures and features of single-layer, multi-layer, and gradient scaffolds with their special mechanical properties. We examined the construction of engineering scaffolds from the perspectives of biomaterials and design strategies, providing a comprehensive evaluation of the advantages and disadvantages associated with each approach. Ultimately, this review articulates clear research directions aimed at achieving breakthroughs in future studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.