ReviewFrontiers in oncology2025
An overview of the current evidences on the role of iron in colorectal cancer: a review.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Iron Metabolism in the Colorectal Tumor Microenvironment: Current Evidence and Clinical Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Iron Metabolism in the Colorectal Tumor Microenvironment: From Preneoplastic Lesions to Cancer Progression.International journal of molecular sciences · 2026Review
- Hepatocyte growth factor alleviates alcoholic cardiomyopathy through the Nrf2 pathway-a focus on iron metabolism.Journal of thoracic disease · 2025Article
- Review
- Sex Hormones and Iron-Related Biomarkers Associate with EMT Features and Tumor Stage in Colorectal Cancer: A Serum- and Tissue-Based Analysis.International journal of molecular sciences · 2025Article
- Decoding iron deficiency in cancer: mechanisms, immune modulation, and therapeutic potential.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is a common and lethal malignancy that affects millions of people worldwide. Iron is an essential micronutrient that plays a vital role in various biological processes, but also has pro-oxidant and pro-inflammatory effects that may contribute to carcinogenesis. The relationship between iron and CRC is complex and influenced by multiple factors, such as dietary intake, absorption, storage, metabolism, and excretion of iron, as well as genetic and environmental factors that modulate iron homeostasis. This review article aims to provide an overview of the current evidences on the role of iron in CRC, discussing the potential mechanisms by which iron may affect CRC development and progression, as well as the implications for prevention and treatment. This review tries to focus on the following aspects: an introduction to iron and its role in CRC, role of heme and non-heme iron in CRC, dietary patterns, nutrition, and CRC, iron overload in CRC, iron deficiency and its role in CRC especially in surgery outcome and iron therapy and blood transfusion in CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.