Evidence mapPaperPMID 40066146Full record

ReviewEuropean heart journal. Imaging methods and practice2025

Impact of technical, patient-related and measurement variables on serial Hounsfield unit-based quantitative coronary plaque analysis in computed tomography: time for a new chapter.

Francesca Calicchio, Elizabeth Epstein, Melinda Boussoussou, Borbála Vattay, Alexander van Rosendael, Shawn Newlander, Márton Kolossváry, Bálint Szilveszter, Pál Maurovich-Horvat, Hugo Marques and 2 more

Abstract readReview
In one paragraph

Review in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca CalicchioDepartment of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.ORCID https://orcid.org/0000-0003-4923-6850
Elizabeth EpsteinDepartment of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.
Melinda BoussoussouHeart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.
Borbála VattayHeart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.
Alexander van RosendaelDepartment of Cardiology, Leiden University Medical Center, 2333 ZA, Leiden, the Netherlands.ORCID https://orcid.org/0000-0003-3088-433X
Shawn NewlanderDepartment of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.
Márton KolossváryDepartment of Cardiology, Gottsegen National Cardiovascular Center, Haller u. 29, 1096 Budapest, Hungary.
Bálint SzilveszterHeart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary.
Pál Maurovich-HorvatMedical Imaging Center, Semmelweis University, Üllői út 78a, 1082 Budapest, Hungary.
Hugo MarquesUNICA Radiology, Hospital da Luz Lisboa, Av. Lusíada 100, Católica Medical School, 1500-650 Lisboa, Portugal.
Elliot McVeighDepartment of Medicine, UC San Diego School of Medicine, 9500 Gilman Dr, 92093 La Jolla, CA, USA.
George WesbeyDepartment of Cardiology and Radiology, Scripps Clinic, 9888 Genesee Ave, La Jolla, CA 92037, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review article explores the challenges and controversies involved in accurately identifying and reliably quantifying coronary plaque over time through coronary computed tomography angiography (CCTA), particularly focusing on lipid-rich, low-attenuation plaques. It highlights significant variability in lipid-rich plaque measurements across studies, questioning their reliability for tracking biological plaque transformation in clinical practice. To address this issue, the review article proposes suggestions for serial CCTA plaque measurements, aiming for realistic goals for reproducible and meaningful serial plaque CCTA imaging. It also emphasizes the necessity of standardized, validated methods for quantitative plaque analysis and underscores the potential of phantom-based calibration to improve the reliability and consistency of serial plaque measurements in clinical practice.

Indexed as

coronary CT angiographyenergy integrating detector CT (EID-CT)low-attenuation plaque (LAP)photon-counting detector CT (PCD-CT)quantitative coronary plaque analysis

Identifiers

PMID40066146
PMCPMC11891479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.