Evidence mapPaperPMID 40066249Full record

ArticleJournal of multidisciplinary healthcare2025

Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis.

Alexander Halim Santoso, Edwin Destra, Yohanes Firmansyah, Susy Olivia Lontoh

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Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander Halim SantosoDepartment of Nutrition, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.
Edwin DestraMaster's Program in Biomedical Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Yohanes FirmansyahDepartment of Physiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.
Susy Olivia LontohDepartment of Physiology, Faculty of Medicine, Tarumanagara University, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcopenia, characterized by a progressive decline in muscle mass and strength, poses significant public health challenges for the elderly, impacting physical performance and quality of life. This study aims to investigate the associations between glucose profile, fasting insulin, renal function, and muscle strength among elderly residents of a single-centered nursing home in Indonesia, identifying potential biomarkers for sarcopenia. Methods: A cross-sectional analysis was conducted on 31 elderly residents of Santa Anna Nursing Home, with muscle strength measured using handgrip dynamometry and biochemical parameters evaluated through standardized laboratory methods. Results: Structural Equation Modeling-Partial Least Squares (SEM-PLS) analysis revealed strong negative correlations between glucose profile (β = -0.683, p < 0.01) and fasting insulin (β = -0.208, p < 0.05) with muscle strength, while renal function showed a moderate positive relationship (β = 0.295, p < 0.05). Conclusion: These findings highlight glucose profile, fasting insulin, and renal function as critical predictors of sarcopenia, offering potential pathways for early detection and targeted interventions. Future research should explore longitudinal assessments and molecular mechanisms to refine sarcopenia prevention strategies in aging populations.

Indexed as

biomarkerselderlyfasting insulinglucose profilemuscle strengthrenal functionsarcopenia

Identifiers

PMID40066249
PMCPMC11892493

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.