Evidence map›Paper›PMID 40066262›Full record

ArticleResearch (Washington, D.C.)2025

Integrated Single-Step Terahertz Metasensing for Simultaneous Detection Based on Exosomal Membrane Proteins Enables Pathological Typing of Gastric Cancer.

Qingzhe Jia, Zhaofu Ma, Yujia Wang, Mingjin Zhang, Guijun Zou, Bin Lan, Songyan Li, Zeqiu Lao, Wenbin Shen, Jing Lou and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Advances in Terahertz Biophysics and Chemistry.Research (Washington, D.C.) · 2025
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Qingzhe JiaDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Zhaofu MaDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Yujia WangDepartment of Traditional Chinese Medicine, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Mingjin ZhangDepartment of General Surgery, The 901st Hospital of PLA, Hefei 230031, Anhui Province, China.
Guijun ZouDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Bin LanDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Songyan LiDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Zeqiu LaoDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Wenbin ShenDepartment of Critical Care Medicine in 83rd Group Army Hospital, Xinxiang City 453000, Henan Province, China.
Jing LouInnovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China.
Yanan JiaoDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.ORCID https://orcid.org/0009-0006-1707-9714
Xiaohui DuDepartment of General Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes (Exos) are emerging as noninvasive biomarkers for diagnosis and progression monitoring of gastric cancer (GC). However, the heterogeneity discrimination and ultrasensitive quantification of Exos presents a considerable analytical challenge, thereby impeding severely their clinical application. Herein, we propose an integrated terahertz metasensing platform for the discrimination of Exos in distinct subtypes of GC in a single step-through the simultaneous evaluation of the category and richness level of Exos membrane proteins. Characterized by dual-sided independent sensing capabilities with enhanced sensitivity (169 and 325 GHz per refractive index unit, respectively), the metasensor functionalized with antibodies simultaneously reflects the content of 2 membrane proteins in the terahertz spectral response. Our approach concurrently completes accurate differentiation and precise quantification of GC-subtype Exos by integrating dual-sided sensing information in merely a single assay. The dual-sided sensing design enhances the reliability of detection results. Moreover, combined with the signal amplification of gold nanoparticles, the platform experimentally demonstrates a superior dynamic response to Exos concentrations spanning from 1 × 10

Identifiers

PMID40066262
PMCPMC11891340

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.