Evidence mapPaperPMID 40066339Full record

ArticleFrontiers in pharmacology2025

Association between statin administration and

Renli Wang, Rongjun Liu, Hua Wang, Zhaojun Xu

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Renli WangDepartment of Intensive Care Unit, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Rongjun LiuDepartment of Anesthesiology, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Hua WangDepartment of Intensive Care Unit, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Zhaojun XuDepartment of Intensive Care Unit, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Existing research suggests that using statins may reduce the incidence of enteritis caused by Methods: Data were collected from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Multivariate logistic regression analysis was employed to assess the impact of statin use on CDE incidence in patients in intensive care units (ICUs) and its effect on in-hospital mortality among them. The research findings were validated by performing propensity score matching (PSM), inverse probability of treatment weighting (IPTW), and subgroup analyses. Results: The study enrolled the data of 51,978 individuals to assess the effect of statin usage on the occurrence of CDE in patients admitted to the ICU. The results indicate that statins can decrease the prevalence of CDE in patients in ICU (odds ratio (OR): 0.758, 95% confidence interval (CI): 0.666-0.873, Conclusion: Statin administration can reduce the incidence of CDE in patients in the ICU; however, it does not decrease the in-hospital mortality rate for individuals with CDE.

Indexed as

Clostridium difficile-induced enteritisincidencein-hospital mortalityintensive care unitMIMIC-IV database

Identifiers

PMID40066339
PMCPMC11891362

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.