Evidence map›Paper›PMID 40066845›Full record

ArticleJournal of neurochemistry2025

Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ

Dila Atak, Erdost Yıldız, Esra Özkan, Mohammadreza Yousefi, Ayşe Özkan, Aysu Bilge Yılmaz, Ali Burak Kızılırmak, Iman Asaad Alnajjar, Çiçek Kanar, Zeynep Lal Caan and 5 more

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dila AtakKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.ORCID 0000-0001-8882-0019
Erdost YıldızKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.ORCID 0000-0001-8086-3524
Esra ÖzkanKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.ORCID 0000-0001-6503-8665
Mohammadreza YousefiKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.
Ayşe ÖzkanKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.
Aysu Bilge YılmazKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.
Ali Burak KızılırmakKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.ORCID 0000-0002-3520-0139
Iman Asaad AlnajjarSchool of Medicine, Koç University, İstanbul, Türkiye.
Çiçek KanarKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.ORCID 0009-0004-9918-2998
Zeynep Lal CaanKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.
Şakir Ümit ZeybekDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, İstanbul University, Istanbul, Türkiye.
Cem İsmail KüçükaliDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, İstanbul University, Istanbul, Türkiye.
Erdem TüzünDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, İstanbul University, Istanbul, Türkiye.
Yasemin Gürsoy-ÖzdemirKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.
Atay VuralKoç University Research Center for Translational Medicine (KUTTAM), Koç University, İstanbul, Türkiye.

Funding

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 116S252Türkiye Bilimsel ve Teknolojik Araştırma Kurumu 119C018
6 · The paper itself

Abstract

Central nervous system (CNS) pericytes play crucial roles in vascular development and blood-brain barrier maturation during prenatal development, as well as in regulating cerebral blood flow in adults. They have also been implicated in the pathogenesis of numerous neurological disorders. However, the behavior of pericytes in the adult brain after injury remains poorly understood, partly due to limitations in existing pericyte ablation models. To investigate pericyte responses following acute ablation and characterize a novel rodent model for pericyte research, we developed a tamoxifen-inducible PDGFRβ

Indexed as

BrainPericytesReceptor, Platelet-Derived Growth Factor betaSpinal CordAnimalsFemaleLongitudinal StudiesMaleMiceMice, Inbred C57BLMice, TransgenicTamoxifenReceptor, Platelet-Derived Growth Factor betaTamoxifenbraincortexinducible PDGFRβ+ cell ablationregenerationspinal cordtamoxifentransgenics

Identifiers

PMID40066845
PMCPMC11894923

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.