Evidence map›Paper›PMID 40067249›Full record

ArticleEpilepsia2025

Unique features of seizure-induced cardiorespiratory failure in SS

Melissa Eilbes, Alexander Gallo, Wasif A Osmani, Paloma Bittencourt-Silva, Anna D Manis, Matthew R Hodges

Abstract read
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melissa EilbesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID https://orcid.org/0009-0006-5972-9981
Alexander GalloDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Wasif A OsmaniDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Paloma Bittencourt-SilvaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Anna D ManisDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Funding

Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
3D PrinterS10OD032136 · OD · MEDICAL COLLEGE OF WISCONSIN · PI TEFFT, BRANDON J · 2022 to 2022
$77k
NHLBI NIH HHS R01 HL122358NIH HHS 1S10OD032136-01NIH HHS HL122358NIH HHS S10 OD032136
6 · The paper itself

Abstract

objectivePatients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure-induced disruption of vital physiological systems. The objective of this study was to characterize seizure-induced physiological dysfunction leading to death in SS

methodsMale and female SS

resultsTime-restricted audiogenic seizures in SS SIGNIFICANCE: Understanding the causes of SUDEP in patients with epilepsy is limited due to unpredictable and heterogeneous circumstances and incomplete physiological data. This study provides insights into seizure-induced and delayed physiological decompensation leading to SUDEP-like events, demonstrating a need for additional prospective, integrated physiological measures for a more complete picture of SUDEP.

Indexed as

Death, SuddenRespiratory InsufficiencySeizuresSudden Unexpected Death in EpilepsyAnimalsBlood PressureBody TemperatureDisease Models, AnimalEpilepsy, ReflexFemaleHeart RateMaleRatsTelemetryepilepsyphysiological decompensationrepeated seizuresSUDEP

Identifiers

PMID40067249
PMCPMC12291026

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.