Evidence map›Paper›PMID 40067490›Full record

Trial reportDiabetes technology & therapeutics2025

Automated Insulin Delivery in Elderly with Type 1 Diabetes: A Prespecified Analysis of the Extension Phase.

Yogish C Kudva, Robert J Henderson, Lauren G Kanapka, Ruth S Weinstock, Michael R Rickels, Richard E Pratley, Naomi Chaytor, Kamille Janess, Donna Desjardins, Vishwanath Pattan and 10 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes technology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04016662 (A Randomized Cross-over Trial Evaluating Automated Insulin Delivery Technologies on Hypoglycemia and Quality of Life in Elderly Adults With Type 1 Diabetes), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04016662 phase4completednot on this map

A Randomized Cross-over Trial Evaluating Automated Insulin Delivery Technologies on Hypoglycemia and Quality of Life in Elderly Adults With Type 1 Diabetes

TypeinterventionalSponsorJaeb Center for Health ResearchRan2020 to 2024Enrolled82ConditionsType 1 Diabetes MellitusArmsTandem t:slim X2 with HCL or PLGS
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yogish C KudvaDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-0285-6622
Robert J HendersonJaeb Center for Health Research, Tampa, Florida, USA.
Lauren G KanapkaJaeb Center for Health Research, Tampa, Florida, USA.ORCID 0000-0003-4440-5168
Ruth S WeinstockDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.ORCID 0000-0001-5859-5666
Michael R RickelsDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9253-838X
Richard E PratleyAdventHealth Translational Research Institute, Orlando, Florida, USA.
Naomi ChaytorElson S. Floyd College of Medicine, Washington State University, Spokane, Washington, USA.
Kamille JanessJaeb Center for Health Research, Tampa, Florida, USA.
Donna DesjardinsDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Vishwanath PattanEndocrinology at Elkhart Clinic, Mishawaka, Indiana, USA.
Amy J PeleckisDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Anna CasuAdventHealth Translational Research Institute, Orlando, Florida, USA.
Shafaq Raza RizviDivision of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2607-4812
Suzan BzdickDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.
Keri J WhitakerAdventHealth Translational Research Institute, Orlando, Florida, USA.
Jorge L Jo KamimotoDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kellee MillerT1D Exchange, St Petersburg, Florida, USA.
Craig KollmanJaeb Center for Health Research, Tampa, Florida, USA.
Roy W BeckJaeb Center for Health Research, Tampa, Florida, USA.ORCID 0000-0002-5194-8446
AIDE Study Group

Funding

Institutional Clinical and Translational Science AwardUL1TR001878 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$10.2M
NCATS NIH HHS UL1 TR001878NIDDK NIH HHS R01 DK122603
6 · The paper itself

Abstract

The Automated Insulin Delivery in Elderly with Type 1 Diabetes (AIDE T1D) trial randomized 82 adults ≥65 years with type 1 diabetes (T1D) to hybrid closed loop (HCL), predictive low glucose suspend (PLGS), and sensor-augmented pump (SAP) therapy in a randomized crossover trial. Seventy-five of the 78 completers joined an extension phase in which they were offered the pump mode of their choice for an additional 3 months. Mean age was 71 ± 4 years (range 65-86 years) and mean duration of T1D was 42 ± 17 years (range 1-68 years). Use of HCL was selected by 91%, PLGS by 8%, and continuous glucose monitoring with injections by 1%. For participants selecting HCL, time-in-range 70-180 mg/dL was similar in the randomized controlled trial and extension phase (mean 75% ± 10%). One severe hypoglycemic event was reported. HCL was preferred over PLGS or SAP and remained effective in older adults with T1D. Clinical Trial Registration: NCT04016662.

Indexed as

Diabetes Mellitus, Type 1Hypoglycemic AgentsInsulinInsulin Infusion SystemsAgedAged, 80 and overBlood GlucoseBlood Glucose Self-MonitoringCross-Over StudiesFemaleHumansHypoglycemiaMaleBlood GlucoseHypoglycemic AgentsInsulinhybrid closed loopolder adultspredictive low glucose suspendtype 1 diabetes

Identifiers

PMID40067490
PMCPMC13398333

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.