Evidence map›Paper›PMID 40067892›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt.

Tania Zaglia, Antonio Campo, Nicola Moro, Vittoria Di Mauro, Giulia Borile, Roberta Menabò, Salvatore Antonucci, Laura Poli, Marika Campesan, Pierluigi Carullo and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. SystemicBiomolecules · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Tania Zaglia *Department of Biomedical Sciences, University of Padova, Padova 35131, Italy.ORCID 0000-0002-3702-3818
Antonio Campo *Department of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Nicola Moro *Department of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Vittoria Di MauroDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.ORCID 0000-0002-4707-4264
Giulia BorileDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Roberta MenabòDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.ORCID 0000-0002-9848-7798
Salvatore AntonucciDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Laura PoliDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Marika CampesanDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Pierluigi CarulloIstituti di Ricovero e Cura a Carattere Scientifico Humanitas Research Hospital, Rozzano, Milan 20089, Italy.ORCID 0000-0003-0812-7770
Sara MartinazziDivision of Cardiac Surgery, University of Verona, Verona 37126, Italy.ORCID 0009-0007-4706-7236
Giovanni B LucianiDivision of Cardiac Surgery, University of Verona, Verona 37126, Italy.ORCID 0000-0003-0931-018X
Karin HammerInternal Medicine II, University Hospital Regensburg, Regensburg 93053, Germany.ORCID 0000-0003-2015-0682
Paola PesceDepartment of Medicine, University of Padova, Padova 35128, Italy.
Riccardo BarianiDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova 35131, Italy.
Giuseppe FaggianDivision of Cardiac Surgery, University of Verona, Verona 37126, Italy.ORCID 0000-0001-5371-5761
Lars MaierInternal Medicine II, University Hospital Regensburg, Regensburg 93053, Germany.ORCID 0000-0001-9915-4429
Laura VenturaDepartment of Statistical Sciences, University of Padova, Padova 35121, Italy.
Diego De StefaniDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Cristina MammucariDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.ORCID 0000-0003-3220-9610
Rosario RizzutoDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.
Daniele CatalucciIstituti di Ricovero e Cura a Carattere Scientifico Humanitas Research Hospital, Rozzano, Milan 20089, Italy.ORCID 0000-0001-7041-6114
Fabio Di LisaDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.ORCID 0000-0003-0705-7539
Marco MongilloDepartment of Biomedical Sciences, University of Padova, Padova 35131, Italy.ORCID 0000-0002-1102-8709

Funding

Università degli Studi di Padova (UNIPD) SID-2022Università degli Studi di Padova (UNIPD) STARS-UNIPD "SkoOp"
6 · The paper itself

Abstract

Regulation of mitochondrial Ca

Indexed as

CalciumCalcium ChannelsCardiomegalyMitochondria, HeartProto-Oncogene Proteins c-aktAnimalsHeart FailureHumansMaleMiceMice, Inbred C57BLMitochondriaMyocardiumMyocytes, CardiacSignal TransductionCalciumCalcium Channelsmitochondrial calcium uniporterProto-Oncogene Proteins c-aktAktbeta adrenergic receptorheart failuremitochondrial calcium uniportermyocardial hypertrophy

Identifiers

PMID40067892
PMCPMC11929399

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.