Evidence map›Paper›PMID 40068019›Full record

ArticleJournal of medicinal chemistry2025

Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1

Jeffrey S Stehouwer, Guofeng Huang, Dinahlee Saturnino Guarino, Manik L Debnath, Ashok Polu, Steven J Geib, Brian Lopresti, Milos D Ikonomovic, Neale Mason, Robert H Mach and 1 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeffrey S StehouwerDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0001-8871-2544
Guofeng HuangDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.
Dinahlee Saturnino GuarinoDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0009-0003-3841-1825
Manik L DebnathDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0009-0007-7260-2501
Ashok PoluDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-6499-3465
Steven J GeibX-ray Crystallography Laboratory, Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-9160-7857
Brian LoprestiDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.
Milos D IkonomovicDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.
Neale MasonDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0001-7739-3285
Robert H MachDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.ORCID 0000-0002-7645-2869
Chester A MathisDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Katherine P Rankin · 2002 to 2026
$67.2M
Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 1985 to 2019
$43.0M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066468NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG023501NINDS NIH HHS U19 NS110456
6 · The paper itself

Abstract

Structure-activity relationship studies were performed on a library of synthesized compounds based on previously identified tau ligands. The top 13 new compounds had

Indexed as

BrainIndolesPositron-Emission TomographyRadiopharmaceuticalsTauopathiesAnimalsFluorine RadioisotopesHumansMaleStructure-Activity RelationshipFluorine RadioisotopesIndolesRadiopharmaceuticals

Identifiers

PMID40068019
PMCPMC11956013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.