Evidence map›Paper›PMID 40068813›Full record

ArticleOpen biology2025

Polycomb-mediated transgenerational epigenetic inheritance of

Maximilian Fitz-James, Poppy Sparrow, Christopher Paton, Peter Sarkies

Abstract read
In one paragraph

Article in Open biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maximilian Fitz-JamesUniversity of Oxford, Oxford, UK.
Poppy SparrowUniversity of Oxford, Oxford, UK.
Christopher PatonUniversity of Oxford, Oxford, UK.
Peter SarkiesUniversity of Oxford, Oxford, UK.ORCID 0000-0003-0279-6199

Funding

John Fell Fund, University of Oxford
6 · The paper itself

Abstract

Transgenerational epigenetic inheritance (TEI) describes the process whereby distinct epigenetic states are transmitted between generations, resulting in heritable gene expression and phenotypic differences that are independent of DNA sequence variation. Chromatin modifications have been demonstrated to be important in TEI; however, the extent to which they require other signals to establish and maintain epigenetic states is still unclear. Here we investigate whether small non-coding RNAs contribute to different epigenetic states of the Fab2L transgene in

Indexed as

DrosophilaDrosophila melanogasterDrosophila ProteinsEpigenesis, GeneticEye ColorPolycomb-Group ProteinsRNA, Small UntranslatedAnimalsGene SilencingHistonesInheritance PatternsMicroRNAsTransgenesDrosophila ProteinsHistonesMicroRNAsPolycomb-Group ProteinsRNA, Small Untranslatedbiorxivepigeneticsopen biologyresearchsiRNAtransgenerational epigenetic inheritance

Identifiers

PMID40068813
PMCPMC11896699

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.