Evidence map›Paper›PMID 40068979›Full record

ReviewTrends in parasitology2025

Cerebral manifestations of falciparum malaria in adults: more than meets the eye.

Samuel C Wassmer, Sanjib Mohanty, Praveen K Sahu, Angelika Hoffmann

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. mBio · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel C WassmerDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: sam.wassmer@lshtm.ac.uk.
Sanjib MohantyDepartment of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India.
Praveen K SahuDepartment of Molecular Biology and Infectious Diseases, Community Welfare Society Hospital, Rourkela, Odisha, India.
Angelika HoffmannInstitute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, University of Bern, Bern, Switzerland.

Funding

Using Next-Generation Genomics to Study Antimalarial Drug Resistance in IndiaU19AI089676 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OMPAD, DANIELLE C · 2010 to 2023
$22.6M
Project2: Developing New Diagnostic Tools for the Detection of Plasmodium Infection Across the Spectrum of Disease SeverityU19AI181587 · NIAID · LONDON SCH/HYGIENE & TROPICAL MEDICINE · PI Sam Wassmer · 2024 to 2026
$2.8M
NIAID NIH HHS U19 AI089676NIAID NIH HHS U19 AI181587
6 · The paper itself

Abstract

The application of neuroimaging techniques to patients with Plasmodium falciparum infection has uncovered a wide range of brain changes not only in cerebral malaria but also in noncomatose patients. We propose several hypotheses to unify findings across the spectrum of clinical malaria in adults and highlight the urgent need to evaluate potential long-term effects of cerebral alterations on neurocognition in this understudied age group.

Indexed as

BrainMalaria, CerebralMalaria, FalciparumAdultHumansNeuroimagingPlasmodium falciparumadultsbrainmagnetic resonance imagingpathogenesisPlasmodium falciparumsevere malaria

Identifiers

PMID40068979
PMCPMC12009473

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.