Evidence map›Paper›PMID 40069361›Full record

ArticleNature neuroscience2025

A curious concept of CNS clearance.

Virginia Plá, Erik Kroesbergen, Saiyue Deng, Michael J Giannetto, Lauren M Hablitz, Evan Newbold, Antonio Ladrón-de-Guevara, Tina Esmail, Ryszard Stefan Gomolka, Yuki Mori and 4 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Virginia Plá *Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5501-0789
Erik Kroesbergen *Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0009-0004-6257-0161
Saiyue DengCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Michael J GiannettoCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-4338-8709
Lauren M HablitzCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-6159-7742
Evan NewboldCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-7497-7824
Antonio Ladrón-de-GuevaraCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-1093-2509
Tina EsmailCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Ryszard Stefan GomolkaCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Yuki MoriCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4208-0005
Steven A GoldmanCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5498-4303
Douglas H KelleyDepartment of Mechanical Engineering, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-9658-2954
John H ThomasDepartment of Mechanical Engineering, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-7127-8654
Maiken NedergaardCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark. nedergaard@urmc.rochester.edu.ORCID http://orcid.org/0000-0001-6502-6031

Funding

Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6M
The glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1M
TRANSCRIPTIONAL DETERMINANTS OF THE FATE TRAJECTORIES OF SINGLE HUMAN GLIAL PROGENITOR CELLS IN RESPONSE TO DEMYELINATION IN VIVOR01NS110776 · NINDS · UNIVERSITY OF ROCHESTER · PI GOLDMAN, STEVEN ALAN · 2019 to 2023
$1.8M
CRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkR01AT012312 · NCCIH · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$1.6M
NCCIH NIH HHS R01 AT011439NCCIH NIH HHS R01 AT012312NINDS NIH HHS R01 NS110776NINDS NIH HHS U19 NS128613
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40069361
PMCPMC12340669

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.