ArticleAging clinical and experimental research2025
Association between Geriatric Nutritional Risk Index and all-cause mortality in individuals with osteoporotic fractures: a retrospective cohort study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Geriatric Nutritional Risk Index and risks of all-cause, cardiovascular, and diabetes-related mortality in adults with obesity: A nationally representative cohort study.American heart journal plus : cardiology research and practice · 2026Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and osteoporotic fracture.Frontiers in medicine · 2026Article
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Authors and funding
9 authors.
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Abstract
backgroundThe number of patients with osteoporotic fractures (OPFs) is on the rise because of global aging. However, few studies have examined the connection between Geriatric Nutritional Risk Index (GNRI) and overall mortality among inpatients with OPFs. Thus, our research seeks to investigate the link between GNRI and overall mortality in inpatients with OPFs.
methodsA retrospective cohort study was investigated on 3143 Kunshan OPFs residents aged ≥ 50 years. Participants were stratified into malnutrition (GNRI ≤ 98) and no malnutrition groups (GNRI > 98). Multivariate Cox regression analyses were utilized to evaluate the connection between GNRI and overall mortality. No non-linear association was detected through smoothed curve fitting and threshold analysis. Kaplan-Meier curves were employed to compare the cumulative risk of mortality across varying nutritional conditions. Subgroup analyses were conducted to further investigate the effects of age, sex and other clinical and laboratory factors on the link between GNRI and mortality.
results3,143 qualified inpatients with OPFs were involved in the final evaluation. Kaplan-Meier curves revealed that the cumulative risk of mortality was markedly elevated in malnutrition group compared to no malnutrition group. In complete adjustments model, malnutrition group showed an adjusted hazard ratio (aHR) of 1.42 [95% CI 1.05, 1.90; P-value = 0.021]. Furthermore, subgroup analyses revealed that no substantial interactions were detected among all variables. (P-interaction > 0.05).
conclusionsReduced GNRI scores are linked to higher mortality in inpatients with OPFs. The GNRI potentially serve as a predictor for overall mortality risk in this population.
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