ArticleBMC genomics2025
Investigation of selection signatures of dairy goats using whole-genome sequencing data.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Integrating landscape genomics and machine learning to analyze the genetic structure and specific molecular markers of Chinese dairy goats (Capra hircus).Journal of animal science and biotechnology · 2026Article
- Integrated SNP and SV Analyses Reveal Genetic Mechanisms Underlying High-Altitude Adaptation in Goats.Animals : an open access journal from MDPI · 2026Article
- Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats.Journal of animal science and biotechnology · 2026Article
- Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Tianhua mutton sheep.BMC genomics · 2026Article
- Population structure, regions of homozygosity (ROH) and selection signal of two domesitic goat breeds revealed by whole-genome resequencing.BMC genomics · 2026Article
- Refining selection signals in dairy sheep using high-density genotyping data.Journal of animal science · 2026Article
- Genetic admixture and adaptive signatures of Guanling cattle revealed by whole-genome sequence.BMC genomics · 2026Article
- GWAS Reveals Key Candidate Genes Associated with Milk-Production in Saanen Goats.Animals : an open access journal from MDPI · 2025Article
- Review
- Article
- Genome-wide identification of selection signals in fat-tailed and thin-tailed sheep populations.Frontiers in genetics · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Dairy goats, a livestock species with a long history of milk production, are essential for the economic advancement of nations, particularly in regions experiencing growth. In this study, we gathered whole-genome resequencing data of 58 goats, including 34 dairy goats and 24 wild goats (Bezoar), to explore the selection signatures linked to milk production traits using ROH (Runs of homozygosity), CLR (composite likelihood ratio), Fst (Fixation index), XP-EHH (Ex-tended haplotype homozygosity across populations) and XP-CLR(Cross-population composite likelihood ratio test) methods. Analysis of five tests of selection signatures for dairy goats revealed a total of 210 genes, with 24 genes consistently identified in at least two approaches. These genes are associated with milk fat, milk protein, and fat yield. Gene enrichment analysis highlighted important GO and KEGG pathways related to milk production, such as the "acyl-CoA metabolic process", "glycerolipid biosynthetic process", "cellular response to fatty ac-id", "hormone metabolic process", "Galactose metabolism". Additionally, genes linked to repro-duction, immune response, and environmental adaptation were identified in dairy goats. The findings from our study offer profound understanding into the critical economic features of dairy goats and offer practical guidance for the improvement and development of crossbreeding initiatives across different dairy goat breeds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.