ArticleBMC psychiatry2025
The relationship between VAI, LAP, and depression and the mediation role of sleep duration-evidence from NHANES 2005-2020.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The mediating role of obesity in the relationship between sleep duration and depressive symptoms: A population-based cross-sectional study.Metabolism open · 2026Article
- An L-shaped association between prognostic nutritional index and all-cause mortality among adults with depressive symptoms: a cohort study using NHANES 2005-2018.BMC psychiatry · 2026Article
- The Associations of Anthropometric Indices With Stages and Mortality in Cardiovascular-Kidney-Metabolic Syndrome: Insights From NHANES.Reviews in cardiovascular medicine · 2026Article
- Association between lipid accumulation product and asthma in US adults: evidence from the NHANES 2005-2020.BMC pulmonary medicine · 2026Article
- Association between visceral adiposity index and hypertension in reproductive-aged women: evidence from NHANES 1999-2023.American journal of cardiovascular disease · 2026Article
- Association between five dietary indices and childhood asthma: the mediating role of visceral adiposity indicators using NHANES data.BMC pediatrics · 2025Article
- Neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) mediates the relationship between abdominal fat index and depression in a cross-sectional study.BMC psychiatry · 2025Article
- Effect of Visceral Adipose Tissue on Major Depressive Disorder: A Mendelian Randomisation Research.Actas espanolas de psiquiatria · 2025Article
- Diabetes influences the link between lipid accumulation products and sarcopenia among US adults, as evidenced by NHANES data.BMC public health · 2025Article
- Analysis of the nonlinear relationships between insulin resistance indicators such as LAP and TyG and depression, and population characteristics: a cross-sectional study.European journal of medical research · 2025Article
- Association between visceral adiposity index and endometriosis: a population-based study.Frontiers in nutrition · 2025Article
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5 authors.
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Abstract
backgroundThe relationship between obesity and mental health has attracted attention. However, large sample studies on the relationship between visceral fat obesity and depression are lacking. This study aimed to explore the relationship between visceral fat obesity and depression by using visceral adiposity index (VAI) and lipid accumulation product (LAP). Additionally, it sought to explore the potential mediating role of sleep duration in these associations.
methodsThe data used in the current cross-sectional investigation are from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2020, including 19,659 participants. Depression was measured using the nine-item Patient Health Questionnaire. Weighted multivariable regression analysis was used to evaluate the correlation of VAI and LAP with depression. The potential non-linear relationship was determined using smooth curve fitting and threshold effect analysis. Additionally, mediation analysis was performed to investigate the potential mediating role of sleep duration. The stability of the relationship was assessed through sensitivity analysis.
resultsVAI and LAP were closely related to depression. In the fully adjusted model, VAI and LAP in the highest quartile increased the association of depression by 52% (OR = 1.52, 95% CI 1.20-1.92, P < 0.001) and 51% (OR = 1.51, 95% CI 1.19-1.91, P < 0.001), respectively, compared with the lowest quartile. Specific saturation effects for VAI, LAP, and depression were identified by smoothed curve fitting, with inflection points of 3.81 and 98.55, respectively. Additionally, mediation analysis revealed that 5.1% and 2.8% of the associations between VAI and LAP with depression were mediated through sleep duration. The results of the sensitivity analysis showed interactions between hypertension and cardiovascular disease in the associations of VAI, and depression (P < 0.05).
conclusionVAI and LAP are associated with depression in US adults. The associations between VAI and LAP with depression are non-linear, which may be mediated through sleep duration. The study highlights the potential of VAI and LAP as valuable tools for the prevention and management of depression.
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