ArticleBMC musculoskeletal disorders2025
T2 mapping and q-Dixon for assessment of intervertebral disc degeneration in lower back pain.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Pathophysiology, diagnosis, and management of discogenic low back pain: a phenotype-driven precision framework for surgical and interventional decision-making.Frontiers in surgery · 2026Review
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8 authors.
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Abstract
backgroundLow back pain(LBP) is very common among the population, and intervertebral disc(IVD) degeneration is considered to be the most common cause of LBP, but the pathophysiological process between IVD degeneration and LBP is not very clear. We conducted this study to clarify the interplay between quantitative magnetic resonance imaging (MRI) parameters, including q-Dixon and T2 mapping, and clinical symptomatology in patients with LBP.
methodsAll LBP patients underwent lumbar spine MRI, encompassing q-Dixon and T2 mapping. The severity of pain was classified based on Oswestry Disability Index (ODI) scores. Midsagittal T2 and T2* mapping were used to assess anterior annulus fibrosus (AAF), nucleus pulposus (NP), and posterior annulus fibrosus (PAF), as well as vertebral bone marrow fat fraction (BMFF). ANOVA and Pearson's correlation analyses facilitated the comparative evaluation of MRI parameters with respect to Pfirrmann grades and ODI scores.
results95 LBP patients were included (41 males, 54 females), with an average age of 44.39 ± 17.44. The T2 values of AAF and PAF were different and weakly correlated between most Pfirrmann grades (r = 0.435, 0.414). T2 and T2* values of NP were different and negatively correlated between all Pfirrmann grades (r=-0.844, -0.704), except for grade IV vs. V, revealing decreasing values for grades I-V. BMFF was different and moderately correlated (r = 0.646) between most Pfirrmann grades, except for grade V vs. grade III and IV. The T2 values of AAF, NP, and PAF, the T2* values of the NP, and the BMFF of the vertebrae could distinguish low pain from moderate and severe pain.
conclusionThe T2 and T2* values of AAF, NP, PAF, as well as the BMFF of the vertebrae, can reflect intervertebral disc (IVD) degeneration and may be potentially used to quantitatively detect causes behind LBP.
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