ArticleBMC public health2025
The association between triglyceride-glucose index and related parameters and risk of tuberculosis infection in American adults under different glucose metabolic states: a cross-sectional study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- TyG Index and Obesity-Related Measures in Relation to All-Cause Mortality Among HSV-Positive Adults.International journal of endocrinology · 2026Article
- Characteristics of indeterminate QuantiFERON-TB Gold PLUS results in pediatric lupus nephritis at Beijing Children's Hospital, 2023-2024.BMC nephrology · 2025Article
- Pan-Immune-Inflammatory value and risk of latent tuberculosis infection.Scientific reports · 2025Article
- Cost-effectiveness analysis of tuberculosis screening in diabetic patients in China: a decision-analytic Markov model.Frontiers in public health · 2025Article
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3 authors.
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Abstract
backgroundTuberculosis (TB) and diabetes mellitus (DM) are known to influence each other, with insulin resistance playing a pivotal role. The relationship between the triglyceride-glucose (TyG) index and its derived indices with the incidence of TB infection across varying glucose metabolic statuses is not well defined.
methodsThis cross-sectional study utilized data from the 2011-2012 National Health and Nutrition Examination Survey. Weighted multivariable regression analysis was employed to explore the correlation between TyG and associated parameters with the incidence of TB infection within different categories of glucose metabolism. Interaction analyses and restricted cubic splines were utilized to assess potential heterogeneity in these associations and to explore the link between TyG and its derivatives with the occurrence of TB infection.
resultsThe study included 4823 participants, of which 668 had TB infection. In individuals with normal glucose tolerance (NGT), the TyG index (OR 2.17, 95%CI 1.40-3.35), TyG-WC (OR 1.01, 95%CI 1.00-1.01), and TyG-BMI (OR 1.02, 95%CI 1.00-1.04) were correlated with TB infection (all P < 0.05). Among participants with impaired fasting glucose (IFG), TyG (OR 57.10, 95%CI 1.17-278.66), TyG-WC (OR 1.02, 95%CI 1.00-1.05), TyG-WHtR (OR 872.94, 95%CI 43.31-17592.72) were significant associated with TB infection (all P < 0.05). However, in those with impaired glucose tolerance (IGT) and DM, TyG and its related parameters did not show an association with TB infection (P > 0.05). The sensitive analysis, converting the TyG index from a continuous variable to a categorical variable (quartiles), revealed an association between the TyG index and an increase risk of TB infection in the NGT and IGT group (quartile 4: OR 2.45 (1.31-4.60) and 761.33 (10.54-54999.02), respectively). No significant association between the TyG index and TB infection was observed in DM and IFG groups.
conclusionsIn participants with NGT and IFG, the levels of the TyG index and its associated parameters were correlated with TB infection. A higher TyG index was independently linked to an increased likelihood of TB infection in individuals with NGT and IGT, but not in DM and IFG.
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