Evidence map›Paper›PMID 40069774›Full record

ArticleMolecular neurodegeneration2025

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurodegeneration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Increased Amyloidogenic Neuronal Injury in HIV-1-infected APP-KI Alzheimer's disease mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lutgarde Serneels *VIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium.
Annerieke Sierksma *VIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium.
Emanuela Pasciuto *VIB Center for Molecular Neurology and Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Ivana GericVIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium.
Arya NairVIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium.
Anna Martinez-MurianaVIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium.
An SnellinxVIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium.
Bart De StrooperVIB Center for Brain and Disease Research and Department of Neurosciences, KU Leuven, Louvain, Belgium. bart.destrooper@kuleuven.be.

Funding

Dementia Research UK MR/Y014847/1FBRI Generation and initial characterization of a humanized CSF1 Knock in model to study microglia function and dysfunctionHORIZON EUROPE European Research Council ERC-834682 CELLPHASE_ADKU Leuven Methusalem grantLeuven Univeristair Fonds The opening the future campaign
6 · The paper itself

Abstract

backgroundRecent studies highlight the critical role of microglia in neurodegenerative disorders, and emphasize the need for humanized models to accurately study microglial responses. Human-mouse microglia xenotransplantation models are a valuable platform for functional studies and for testing therapeutic approaches, yet currently those models are only available for academic research. This hampers their implementation for the development and testing of medication that targets human microglia.

methodsWe developed the hCSF1

resultsOur results demonstrate the successful transplantation of iPSC-derived human microglia into the brains of hCSF1

conclusionThe hCSF1

Indexed as

Alzheimer DiseaseDisease Models, AnimalMicrogliaNeurodegenerative DiseasesAnimalsHumansMiceMice, TransgenicAlzheimer’s diseaseMicrogliaMouse xenotransplantation model

Identifiers

PMID40069774
PMCPMC11895352

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.