Evidence map›Paper›PMID 40069841›Full record

ArticleCell division2025

RFX2 downregulates RASSF1 expression and YAP phosphorylation through Hippo signaling to promote immune escape in lung adenocarcinoma.

Zhenzhen Kong, Ping Zhou, Jiahao Xu, Ying Zhang, Yong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell division, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhenzhen Kong *Department of Laboratory, Wujin Hospital Affiliated With Jiangsu University, No. 2 of Yongning North Road, Changzhou, 213002, Jiangsu, People's Republic of China.
Ping Zhou *Department of Medical Laboratory, Xuzhou Mining Group General Hospital, Xuzhou, 221011, Jiangsu, People's Republic of China.
Jiahao XuDepartment of Laboratory, Wujin Hospital Affiliated With Jiangsu University, No. 2 of Yongning North Road, Changzhou, 213002, Jiangsu, People's Republic of China.
Ying ZhangDepartment of Laboratory, Wujin Hospital Affiliated With Jiangsu University, No. 2 of Yongning North Road, Changzhou, 213002, Jiangsu, People's Republic of China.
Yong WangDepartment of Laboratory, Wujin Hospital Affiliated With Jiangsu University, No. 2 of Yongning North Road, Changzhou, 213002, Jiangsu, People's Republic of China. wyong827@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRegulatory Factor X (RFX) transcription factors have been implicated in different cancers. Ras association domain family (RASSF) has been shown clinical significance in lung cancer. This paper was to investigate the interaction of RFX2 and RASSF1 in lung adenocarcinoma (LUAD).

methodsThe transcriptome differences of LUAD patients in GSE32863, GSE43458, and GSE21933 datasets were analyzed. A-549 and NCI-H358 cell lines after overexpression of RFX2 were co-cultured with activated CD8

resultsRFX2 was notably downregulated in LUAD. RFX2 overexpression increased infiltrating CD8

conclusionRFX2 Loss in LUAD downregulates RASSF1 expression and YAP phosphorylation, thereby promoting immune escape through Hippo signaling.

Indexed as

Hippo signaling pathwayImmune escapeLung adenocarcinomaRASSF1RFX2

Identifiers

PMID40069841
PMCPMC11895337

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.