Evidence map›Paper›PMID 40070045›Full record

ArticleJournal of cellular and molecular medicine2025

Phosphodiesterase 10A Inhibitor Modulates Right Ventricular Outflow Tract Electrophysiological Activities and Calcium Homeostasis via the cGMP/PKG Pathway.

Feng-Zhi Lin, Yao-Chang Chen, Hsiang-Yu Yang, Wei-Shiang Lin, Yen-Yu Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feng-Zhi LinDepartment of Biomedical Engineering and Institute of Physiology, National Defense Medical Center, Taipei, Taiwan.
Yao-Chang ChenDepartment of Biomedical Engineering and Institute of Physiology, National Defense Medical Center, Taipei, Taiwan.
Hsiang-Yu YangGrade Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.ORCID 0000-0001-7636-2663
Wei-Shiang LinDivision of Cardiology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yen-Yu LuFu Jen Catholic University, School of Medicine, New Taipei City, Taiwan.

Funding

Ministry of National Defense-Medical Affairs Bureau MND-MAB-D-111129Ministry of National Defense-Medical Affairs Bureau MND-MAB-D-114079Tri-Service General Hospital TSGH-C01-113032
6 · The paper itself

Abstract

Phosphodiesterase inhibitors regulate intracellular Ca

Indexed as

CalciumCyclic GMPCyclic GMP-Dependent Protein KinasesElectrophysiological PhenomenaHeart VentriclesPhosphodiesterase InhibitorsPhosphoric Diester HydrolasesAction PotentialsAnimalsCalcium-Binding ProteinsCalcium Channels, L-TypeCarbazolesHomeostasisIsoproterenolMaleMyocytes, CardiacCalciumCalcium-Binding ProteinsCalcium Channels, L-TypeCarbazolesCyclic GMPCyclic GMP-Dependent Protein KinasesIsoproterenolKT 5823Phosphodiesterase InhibitorsPhospholambanPhosphoric Diester HydrolasesSodium-Calcium ExchangerCa2+ regulationphosphodiesterase 10A inhibitorright ventricular outflow tract

Identifiers

PMID40070045
PMCPMC11897058

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.