Evidence map›Paper›PMID 40070549›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Injective hydrogel encapsulating dental pulp stem cells for the treatment of traumatic optic nerve injury.

Lihua Luo, Zhenjie Xing, Yao Li, Ben Wang, Na Dong, Jiayi Sun, Shuimiao Wang, Yidi Xu, Yan He, Lingli Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lihua Luo *School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhenjie Xing *School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yao Li *The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ben WangSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Na DongSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jiayi SunSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shuimiao WangThe Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yidi XuSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yan HeTianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Lingli LiThe Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Kaihui NanThe Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qingsong YeCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The study aimed to evaluate the effect of GeLMA/bFGF hydrogel loaded with dental pulp stem cells (DPSCs) on the repair and regeneration of traumatic optic nerve injury. Materials and methods: GeLMA/bFGF hydrogel was photo-cross-linked by LED light. The physical-chemical properties and cytocompatibility of GeLMA/bFGF hydrogel after being squeezed (GeLMA/bFGF-SQ) were evaluated by SEM and degradation analyses, as well as live/dead and CCK-8 assays, respectively. The axon growth of PC12 cells was evaluated by MAP2 staining. The GeLMA/bFGF/DPSCs-SQ hydrogel was injected Results: GeLMA/bFGF-SQ hydrogel had a porous structure and great degradability, as well as good cytocompatibility. Meanwhile, DPSCs-conditioned medium (DPSCs-CM) could promote the axon growth of PC12 cells. Moreover, the number of RGCs and the regeneration of axons of the optic nerve were the highest in the GeLMA/bFGF/DPSCs-SQ group. HE and TEM data revealed abundant newly and orderly arrangement of optic nerve axons that was observed in the damaged area of the GeLMA/bFGF/DPSCs-SQ group. Conclusion: Transplantation of GeLMA/bFGF/DPSCs-SQ

Indexed as

basic fibroblast growth factordental pulp stem cellshydrogelretinal ganglion cellstraumatic optic nerve injury

Identifiers

PMID40070549
PMCPMC11893850

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.