ArticleJournal of inflammation research2025
Preoperative SII Can Predict Postoperative Recurrence and Serious Complications in Patients with Hepatolithiasis.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association of Systemic Inflammatory Biomarkers (NLR, MLR, PLR, SII, SIRI) with Preeclampsia-Related Kidney Injury: A Retrospective Observational Study.Journal of inflammation research · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The occurrence and progression of hepatolithiasis are related to inflammatory reactions and immune proteins. This study aims to evaluate the relationship between systemic immune index (SII) in recurrence-free survival (RFS), as well as the incidence of severe postoperative complications in hepatolithiasis patients. Patients and Methods: We retrospectively analyzed 177 patients with hepatolithiasis. The optimal cut-off values of SII, systemic inflammatory response index (SIRI), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR) and prognostic nutritional index (PNI) were evaluated by the analysis of the receiver operating characteristic (ROC) curve. The relationship between SII, SIRI, NLR and clinical results was tested with Results: The analysis of the ROC curve determines the optimal cut-off value and the area under the curve (AUC) of SII, SIRI, NLR, MLR, PLR and PNI, and then grouped. In the multivariate analysis, surgical method (HR=3.331, 95% CI: 1.360-8.158, p=0.008) and SII (HR=2.883, 95% CI: 1.084-7.668, p=0.034) were identified as independent risk factors for serious postoperative complications; the multivariate cox regression analysis demonstrated that a history of gallstones (HR=1.965, 95% CI: 1.206-3.201, p=0.007), SII (HR=2.818, 95% CI: 1.340-5.926, p=0.006), and MLR (HR=3.240, 95% CI: 1.158-9.067, p=0.025) were independent risk factors for RFS; survival analysis results show that patients with low levels of SII (p<0.001), SIRI (p=0.005), and NLR (p<0.001) had significantly higher RFS compared to those in the high-level group. Conclusion: Preoperative high levels of SII, SIRI, and NLR are associated with postoperative recurrence in patients with hepatolithiasis, with SII identified as an independent risk factor for both postoperative RFS and serious complications.
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