Evidence map›Paper›PMID 40071072›Full record

ArticleSovremennye tekhnologii v meditsine2025

Study of Brain Cells in Neurodegenerative Diseases: Raman Microspectroscopy and Scanning Ion-Conductance Microscopy.

K I Morozova, E Yu Parshina, T A Kazakova, A I Yusipovich, O V Slatinskaya, A R Brazhe, I A Grivennikov, N A Brazhe, G V Maksimov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

K I MorozovaJunior Researcher, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia.
E Yu ParshinaPhD, Senior Researcher, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia.
T A KazakovaEngineer, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia.
A I YusipovichPhD, Senior Researcher, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia.
O V SlatinskayaPhD, Junior Researcher, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia.
A R BrazhePhD, Senior Researcher, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia; Senior Researcher, Neuron-Glial Dynamics Group; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russia.
I A GrivennikovDSc, Professor, Chief Researcher, Laboratory of Molecular Neurogenetics and Innate Immunity; National Research Center "Kurchatov Institute", 1 Akademika Kurchatova Square, Moscow, 123182, Russia.
N A BrazhePhD, Leading Researcher, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia; Senior Researcher, Redox Neurobiology Group; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow, 117997, Russia.
G V MaksimovDSc, Professor, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia; Professor, Department of Physical Materials; National University of Science and Technology "MISIS", 4 Leninsky Prospect, Moscow, 119049, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: By using Raman spectroscopy and scanning ion-conductance microscopy, the researchers studied the morphology and state of molecules in rat brain neurons and astrocytes induced from pluripotent stem cells of healthy donors and patients with hereditary Parkinson's disease. Results: The researchers established that typical bands of Raman and surface-enhanced Raman spectra of neurons and astrocytes allowed studying the distribution and conformation of a series of biological molecules (proteins, lipids, cytochromes) in healthy and unhealthy states. It was shown that in Parkinson's disease, there was a decrease in the protein content and an increase in the proportion of reduced cytochromes in the respiratory chain of astrocyte mitochondria. When comparing the morphology of astrocyte bodies and processes, it was established that the height and cross-sectional area of astrocyte processes obtained from cells of patients with hereditary Parkinson's disease were significantly greater than in healthy patients. Conclusion: The developed approach to recording the distribution and conformation of molecules in neurons and astrocytes, as well as to studying the morphology of astrocyte processes allows diagnosing the functional state of cells and investigating the mechanism of the Parkinson's disease pathogenesis.

Indexed as

AstrocytesBrainNeurodegenerative DiseasesNeuronsParkinson DiseaseSpectrum Analysis, RamanAnimalsHumansRatsastrocyteneuronplasmonic silver nanostructurespluripotent stem cellsRaman spectroscopyscanning ionconductance microscopysurface-enhanced Raman spectroscopy

Identifiers

PMID40071072
PMCPMC11892573

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.