Evidence map›Paper›PMID 40071074›Full record

ArticleSovremennye tekhnologii v meditsine2025

Cytoprotective Action of Sodium Fumarate in an

A Yu Vinokurov, S V Popov, D Yu Belyakov, D Yu Popov, A S Nikulin, V D Zakrzhevskaya, R G Guseinov, K V Sivak, A V Dunaev, E V Potapova and 1 more

Abstract read
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In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A Yu VinokurovPhD, Senior Researcher, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia.
S V PopovMD, DSc, Professor, Chief Physician; Clinical Hospital of St. Luke, 46 letter A, Chugunnaya St., Saint Petersburg, 194044, Russia; Head of the City Center for Endoscopic Urology and New Technologies; Clinical Hospital of St. Luke, 46 letter A, Chugunnaya St., Saint Petersburg, 194044, Russia; Professor, Department of Urology; Military Medical Academy, 6 letter Zh, Akademika Lebedeva St., Saint Petersburg, 194044, Russia; Head of the Department of Surgery and Urology; Saint Petersburg Medical and Social Institute, 72 letter A, Kondratyevsky Prospekt, Saint Petersburg, 195271, Russia.
D Yu BelyakovLaboratory Assistant, Laboratory of Cell Physiology and Pathology, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia.
D Yu PopovResearch Intern, Laboratory of Cell Physiology and Pathology, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia.
A S NikulinStudent; Novosibirsk State University, 1 Pirogova St., Novosibirsk, 630090, Russia.
V D ZakrzhevskayaLaboratory Assistant, Laboratory of Cell Physiology and Pathology, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia.
R G GuseinovMD, PhD, Deputy Chief Physician for Research; Clinical Hospital of St. Luke, 46 letter A, Chugunnaya St., Saint Petersburg, 194044, Russia; Senior Lecturer, Department of Surgery and Urology; Saint Petersburg Medical and Social Institute, 72 letter A, Kondratyevsky Prospekt, Saint Petersburg, 195271, Russia; Assistant Professor, Department of Hospital Surgery; Saint Petersburg State University, 7/9 Universitetskaya naberezhnaya St., Saint Petersburg, 199034, Russia.
K V SivakDSc, Leading Researcher; Clinical Hospital of St. Luke, 46 letter A, Chugunnaya St., Saint Petersburg, 194044, Russia; Head of the Department of Preclinical Studies of Medications; A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of the Russian Federation, 15/17 Professora Popova St., Saint Petersburg, 197376, Russia.
A V DunaevDSc, Leading Researcher, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia.
E V PotapovaPhD, Senior Researcher, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia.
A Yu AbramovDSc, Head of the Laboratory of Cell Physiology and Pathology, Research and Development Center of Biomedical Photonics; Orel State University, 95 Komsomolskaya St., Orel, 302026, Russia; Professor; UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia is a part of many pathological and some physiological processes. It also occurs as a result of surgical techniques associated with limiting the blood supply to the operated organs and tissues. Hypoxia leads to a significant decrease in the ability of cells to implement energy-dependent processes due to a reduced contribution of mitochondria to the synthesis of adenosine triphosphate (ATP). In order to protect cells and increase the time of surgery, infusion of a solution of sodium fumarate for several days before the surgical procedure is suggested. However, the mechanism of the observed protective effect is still a subject of discussion. Materials and Methods: The study was conducted using the MDCK renal epithelial cell line with sodium dithionite at a concentration of 5 mM to create hypoxic conditions. The parameters of cellular metabolism (including the value of mitochondrial membrane potential, the state of mitochondrial NADH and FAD, the content of Ca Results: It was demonstrated that the use of sodium dithionite allows modeling acute hypoxia Conclusion: At the cellular level, using an optimized hypoxia model, the study revealed the mechanism of the protective role of sodium fumarate, which explained the antihypoxant effectiveness in assisted ischemia of organs and tissues.

Indexed as

DithioniteFumaratesHypoxiaAnimalsCell HypoxiaDogsEpithelial CellsMadin Darby Canine Kidney CellsMembrane Potential, MitochondrialMitochondriaOxygenDithioniteFumaratesOxygenapoptosiscell culturehypoxiasodium dithionitesodium fumarate

Identifiers

PMID40071074
PMCPMC11892570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.