Evidence map›Paper›PMID 40071689›Full record

ArticleEuropean journal of immunology2025

Vaginal Prevotella timonensis Bacteria Enhance HIV-1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets.

Marleen Y van Smoorenburg, Ester B M Remmerswaal, Celia Segui-Perez, John L van Hamme, Karin Strijbis, Teunis B H Geijtenbeek

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Innate Immune Protection Against HIV in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marleen Y van SmoorenburgDepartment of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-2413-0136
Ester B M RemmerswaalDepartment of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Celia Segui-PerezDepartment of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands.
John L van HammeDepartment of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Karin StrijbisDepartment of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands.
Teunis B H GeijtenbeekDepartment of Experimental Immunology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-5710-2839

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Young females are at high risk of acquiring HIV-1 infections and an imbalance in the vaginal microbiome enhances susceptibility to HIV-1 infection. More insights into the underlying mechanisms could open up new strategies to prevent HIV-1 acquisition and dissemination. Here, we investigated the effect of anaerobic bacteria associated with bacterial vaginosis (BV) on HIV-1 transmission by two distinct dendritic cell (DC) subsets, that is, inflammatory monocyte-derived DCs (moDCs) and primary CD1c

Indexed as

Bacteroidaceae InfectionsDendritic CellsHIV-1HIV InfectionsPrevotellaVaginaVaginosis, BacterialAntigens, CD1Cells, CulturedFemaleGlycoproteinsHumansMicrobiotaAntigens, CD1CD1C protein, humanGlycoproteinsdendritic cells (DCs)HIV‐1 susceptibilityPrevotella timonensisprimary CD1c+ DCstransmissionvaginal dysbiosisvaginal microbiomeviral uptake

Identifiers

PMID40071689
PMCPMC11898549

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.