Evidence map›Paper›PMID 40072079›Full record

ArticleCells2025

Chronic Pain Induced by Social Defeat Stress in Juvenile Mice Depends on TLR4.

Julia Borges Paes Lemes, Alisa Panichkina, Kaue Franco Malange, Carlos E Morado-Urbina, Sara Anna Dochnal, Saee Jadhav, Maksim Dolmat, Marco Pagliusi, Juliana M Navia-Pealez, Maripat Corr and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julia Borges Paes LemesDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.ORCID 0000-0003-2212-6803
Alisa PanichkinaDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.
Kaue Franco MalangeDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.ORCID 0000-0001-5381-6730
Carlos E Morado-UrbinaDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.
Sara Anna DochnalDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.ORCID 0000-0003-3011-567X
Saee JadhavDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.
Maksim DolmatDepartment of Chemical and Nano Engineering, University of California, San Diego, CA 92093, USA.
Marco PagliusiDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Sao Paulo 14049-900, Brazil.ORCID 0000-0002-8379-9131
Juliana M Navia-PealezDepartment of Pharmacology and Physiology, Saint Louis University, Saint Louis, MO 63104, USA.
Maripat CorrDepartment of Medicine, University of California, San Diego, CA 92093, USA.
Yury I MillerDepartment of Medicine, University of California, San Diego, CA 92093, USA.ORCID 0000-0003-0521-7690
Tony L YakshDepartment of Anesthesiology, University of California, San Diego, CA 92093, USA.

Funding

Role of TLR4-lipid rafts in nociceptionR01NS132483 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Patrick M Dougherty, Yury Miller · 2024 to 2026
$2.3M
NEURAXIAL AAVS TARGETING DRG CHANNELS INVOLVED IN CHRONIC POST INFLAMMATORY PAINR01NS131560 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TONY L. YAKSH · 2024 to 2026
$1.8M
NIH HHS R01NS131560NIH HHS R01NS132483NINDS NIH HHS R01 NS131560NINDS NIH HHS R01 NS132483
6 · The paper itself

Abstract

A significant portion of adolescents suffer from mental illnesses and persistent pain due to repeated stress. The components of the nervous system that link stress and pain in early life remain unclear. Prior studies in adult mice implicated the innate immune system, specifically Toll-like receptors (TLRs), as critical for inducing long-term anxiety and pain-like behaviors in social defeat stress (SDS) models. In this work, we investigated the pain and anxiety behavioral phenotypes of wild-type and TLR4-deficient juvenile mice subjected to repeated SDS and evaluated the engagement of TLR4 by measuring dimerization in the spinal cord, dorsal root ganglia, and prefrontal cortex. Male juvenile (4-week-old) mice (C57BL/6J or

Indexed as

Chronic PainSocial DefeatStress, PsychologicalToll-Like Receptor 4AnimalsAnxietyBehavior, AnimalGanglia, SpinalHyperalgesiaMaleMiceMice, Inbred C57BLMice, KnockoutSpinal CordTlr4 protein, mouseToll-Like Receptor 4dorsal root gangliapainsocial stressspinal cordTLR4

Identifiers

PMID40072079
PMCPMC11898947

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.