Evidence map›Paper›PMID 40072094›Full record

ArticleCells2025

Spheroids Composed of Reaggregated Neonatal Porcine Islets and Human Endothelial Cells Accelerate Development of Normoglycemia in Diabetic Mice.

Mohsen Honarpisheh, Yutian Lei, Antonia Follenzi, Alessia Cucci, Cristina Olgasi, Ekaterine Berishvili, Fanny Lebreton, Kevin Bellofatto, Lorenzo Piemonti, Antonio Citro and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mohsen HonarpishehMedizinische Klinik und Poliklinik IV, Diabetes Zentrum, Klinikum der Universität München, LMU Munich, 80336 Munich, Germany.
Yutian LeiMedizinische Klinik und Poliklinik IV, Diabetes Zentrum, Klinikum der Universität München, LMU Munich, 80336 Munich, Germany.ORCID 0000-0001-6552-7645
Antonia FollenziDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
Alessia CucciDepartment of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-5003-831X
Cristina OlgasiDepartment of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-5738-213X
Ekaterine BerishviliTissue Engineering and Organ Regeneration Lab, University of Geneva, Department of Surgery, CH-1211 Geneva, Switzerland.ORCID 0000-0002-7969-1937
Fanny LebretonTissue Engineering and Organ Regeneration Lab, University of Geneva, Department of Surgery, CH-1211 Geneva, Switzerland.
Kevin BellofattoTissue Engineering and Organ Regeneration Lab, University of Geneva, Department of Surgery, CH-1211 Geneva, Switzerland.
Lorenzo PiemontiDiabetes Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-2172-2198
Antonio CitroDiabetes Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-0947-7687
Francesco CampoDiabetes Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0001-5609-8084
Cataldo PignatelliDiabetes Research Institute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-4231-0504
Olivier ThaunatCentre International de Recherche en Infectiologie, Université Claude Bernard Lyon I, 69364 Lyon, France.
Elisabeth KemterMolecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.
Martin KraetzlMolecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.ORCID 0000-0002-8449-177X
Eckhard WolfMolecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, 80539 Munich, Germany.
Jochen SeisslerMedizinische Klinik und Poliklinik IV, Diabetes Zentrum, Klinikum der Universität München, LMU Munich, 80336 Munich, Germany.
Lelia Wolf-van BuerckMedizinische Klinik und Poliklinik IV, Diabetes Zentrum, Klinikum der Universität München, LMU Munich, 80336 Munich, Germany.
Vanguard Consortium

Funding

Deutsche Forschungsgemeinschaft Transregional Collaborative Research Center SFB 127European Commission Horizon 2020 Framework Program; VANGUARD grant 874700
6 · The paper itself

Abstract

The engraftment of transplanted islets depends on the rapid establishment of a novel vascular network. The present study evaluated the effects of cord blood-derived blood outgrowth endothelial cells (BOECs) on the viability of neonatal porcine islets (NPIs) and the post-transplant outcome of grafted NPIs. Dispersed NPIs and human BOECs were reaggregated on microwell cell culture plates and tested for their anti-apoptotic and pro-angiogenic capacity by qRT-PCR and immunohistochemistry. The in vivo functionality was analyzed after transplantation into diabetic NOD-SCID IL2rγ

Indexed as

Diabetes Mellitus, ExperimentalEndothelial CellsIslets of LangerhansIslets of Langerhans TransplantationSpheroids, CellularAnimalsAnimals, NewbornHumansMiceMice, Inbred NODMice, SCIDNeovascularization, PhysiologicSwineblood outgrowth endothelial cellsneonatal porcine islet-like cell clustersreaggregated cell clustersxenotransplantation

Identifiers

PMID40072094
PMCPMC11898817

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.