Evidence mapPaperPMID 40072921Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2025

Effect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism.

Ericka M Biagioni, John C Rowe, Sripallavi Yendamuri, Breanna L Wisseman, Donghai Zheng, Guofang Zhang, Deborah M Muoio, James E DeVente, Kelsey H Fisher-Wellman, P Darrell Neufer and 2 more

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ericka M BiagioniDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.ORCID 0009-0003-7507-1604
John C RoweDepartment of Obstetrics and Gynecology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States.
Sripallavi YendamuriDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.
Breanna L WissemanDepartment of Kinesiology, University of Rhode Island, Kingston, Rhode Island, United States.ORCID 0000-0001-9535-1011
Donghai ZhengDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.
Guofang ZhangDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States.ORCID 0000-0003-3484-5864
Deborah M MuoioDuke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States.
James E DeVenteEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0001-9173-6061
Kelsey H Fisher-WellmanSchool of Medicine, Wake Forest University, Winston-Salem, North Carolina, United States.ORCID 0000-0002-0300-829X
P Darrell NeuferSchool of Medicine, Wake Forest University, Winston-Salem, North Carolina, United States.
Linda E MayDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0002-8231-2280
Nicholas T BroskeyDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0002-1197-5116

Funding

Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell MetabolismR01DK137945 · EAST CAROLINA UNIVERSITY · 2025 to 2025
$473k
HHS | National Institutes of Health (NIH) R01DK137945NIDDK NIH HHS R01 DK137945
6 · The paper itself

Abstract

Offspring exposed to metformin treatment for gestational diabetes mellitus (GDM) experience altered growth patterns that increase the risk for developing cardiometabolic diseases later in life. The adaptive cellular mechanisms underlying these patterns remain unclear. Therefore, the objective of this study was to determine whether chronic in utero metformin exposure associated with GDM treatment elicits infant cellular metabolic adaptations. In a cross-sectional design, 22 pregnant women diagnosed with GDM and treated exclusively with metformin (Met;

Indexed as

Diabetes, GestationalHypoglycemic AgentsMesenchymal Stem CellsMetforminPrenatal Exposure Delayed EffectsAdultCells, CulturedCross-Sectional StudiesEnergy MetabolismFemaleHumansInfant, NewbornMitochondriaPregnancyHypoglycemic AgentsMetformingestational diabetesmesenchymal stem cellsmetabolismmetforminmitochondria

Identifiers

PMID40072921
PMCPMC12051473

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.