ArticleScience advances2025
Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Ingested plastics reduce recruitment and survival of an Australian seabird.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The hidden world of nanoplastics colliding with neurodegenerative diseases.The Journal of clinical investigation · 2026Article
- Biodegradable polylactic acid microplastics rewire the soil food web by impeding amoebae predation.The ISME journal · 2026Article
- Inviting ecosystems into the exposome framework.Exposome · 2026Article
- Revealing the risk of macroplastic ingestion to marine wildlife.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bottom Sediments as Dynamic Arenas for Anthropogenic Pollutants: Profiling Sources, Unraveling Fate Mechanisms, and Assessing Ecological Consequences.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding plastics' harmful impacts on wildlife would benefit from the application of hypothesis agnostic testing commonly used in medical research to detect declines in population health. Adopting a data-driven, proteomic approach, we assessed changes in 745 proteins in a free-living nonmodel organism with differing levels of plastic exposure. Seabird chicks heavily affected by plastic ingestion demonstrated a range of negative health consequences: Intracellular components that should not be found in the blood were frequently detected, indicative of cell lysis. Secreted proteins were less abundant, indicating that the stomach, liver, and kidneys are not functioning as normal. Alarmingly, these signatures included evidence of neurodegeneration in <90-day-old seabird chicks with high levels of ingested plastic. The proteomic signatures reflect the effects of plastic distal to the site of exposure (i.e., the stomach). Notably, metrics commonly used to assess condition in wildlife (such as body mass) do not provide an accurate description of health or the impacts of plastic ingestion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.