ArticleArchives of gerontology and geriatrics2025
Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults.
Article in Archives of gerontology and geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The association of thigh myosteatosis with lower cognitive function in older cancer survivors.GeroScience · 2026Article
- Myosteatosis: an emerging biomarker of aging.Frontiers in aging · 2026Review
- Article
- Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
- Update of
Authors and funding
7 authors.
Funding
Abstract
backgroundPrior research linking myosteatosis with cognition in older adults has been conducted in relatively homogenous populations with narrow age ranges. We evaluated if abdominal myosteatosis was associated with processing speed in a multiethnic cohort of middle aged and older adults.
methodsThe sample included 1,268 adults (46-86 years-old, mean 63±9 years, 53 % female, 41 % White, 20 % Black, 14 % Chinese, and 25 % Hispanic), a subset from the Multi-Ethnic Study of Atherosclerosis. Bivariate analyses examined the relationships between abdominal computed tomography-derived muscle density (measure of myosteatosis) at clinical exam 3, Digit Symbol Coding (DSC) performance at clinical exam 5, and cytokine levels from clinical exam 1. Multivariable models were adjusted for demographics, education, general cognition, and further adjusted for other known predictors of dementia: APOE-4, physical activity, diabetes, cholesterol, smoking, and blood pressure. We assessed whether central adiposity, general adiposity, and cytokines modified this association. We tested interactions by ethnicity, sex, and age.
resultsRectus abdominis myosteatosis was significantly associated with worse DSC (B=-0.247, 95 % CI: 0.098,0.396, p = 0.001) independent of demographics, education, general cognition, and dementia risk factors. Adjustment for central adiposity, and cytokines did not attenuate the associations and interactions by ethnicity, sex, and age were not statistically significant.
conclusionsRectus abdominis myosteatosis is associated with worse processing speed in this middle and older aged multiethnic population of men and women, independent of known predictors of cognition. Longitudinal studies should assess the interplay of myosteatosis with other markers of adiposity, inflammation, and circulating mediators and their impact on processing speed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.