Evidence map›Paper›PMID 40073996›Full record

ArticleEuropean journal of dentistry2025

Evaluation of Regeneration Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Induced Damaged Submandibular Salivary Gland in Mice.

Nadia Attia Radi, Doaa Adel Habba, Seham Ibrahim Hallool, Ahmed Ali Almeshari, Hanaa Mohamed Abd Elsamia

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In one paragraph

Article in European journal of dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nadia Attia RadiDepartment of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.ORCID 0009-0003-8925-7872
Doaa Adel HabbaDepartment of Oral and Dental Pathology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.ORCID 0009-0000-1459-782X
Seham Ibrahim HalloolDepartment of Oral and Dental Biology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.ORCID 0000-0002-5820-5493
Ahmed Ali AlmeshariDepartment of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Najran University, Kingdom of Saudi Arabia.ORCID 0009-0000-2150-3203
Hanaa Mohamed Abd ElsamiaDepartment of Oral and Maxillofacial Pathology, Faculty of Oral and Dental Surgery and Medicine, Zagazing University, Zagazing, Egypt.ORCID 0000-0003-0415-8609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe ultimate goal of stem cell (SC) transplantation is the regeneration of salivary gland function by transplanted SCs differentiating into salivary gland cells. Therefore, this study aimed to evaluate the regenerative capacity of bone marrow-derived mesenchymal stem cells (BM-MSCs) transplantation in irradiated mice using the immunohistochemical markers Ki-67 and CD34. MATERIAL AND

methodsFour groups of male mice were included in the study. Group I (normal control) comprised six mice that were not subjected to gamma radiation. Group II comprised six irradiated mice that were not treated with BM-MSCs. Group III comprised 12 irradiated mice that were treated with intraglandular injection of labeled BM-MSCs into their submandibular salivary glands, 24 hours postradiation. Group IV comprised 12 irradiated mice that were treated with intraglandular injection of labeled BM-MSCs into their submandibular salivary glands, on day 11 postradiation. STATISTICAL ANALYSIS: Data were presented as mean and standard deviation. The different groups were compared using a one-way analysis of variance (ANOVA).

resultsThe ANOVA test revealed that the difference between all groups was extremely statistically significant (

conclusionBM-MSCs have a regeneration potential on induced damaged submandibular salivary glands in mice; time is an essential factor in the regeneration capacity of BM-MSCs.

Identifiers

PMID40073996
PMCPMC12182395

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.