ArticleJournal of cellular and molecular medicine2025
Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Crossroads of Neurodegeneration: Exploring the Overlap Between Alzheimer's Disease and Depression.Cureus · 2026Review
- Revealing the Diagnostic Potential of Three RHO GTPase-Related Genes in Osteoarthritis Based on Single-Cell RNA Sequencing and GEO Dataset Analysis.International journal of genomics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The purpose of this study was to recognise predictive biomarkers and explore the promising therapeutic targets of AD with depression. We confirmed a positive correlation between AD and depression through MR Analysis. Through WGCNA analysis, we identified 1569 genes containing two modules, which were most related to AD. In addition, 1629 depressive DEGs were also identified. In these genes, 84 genes were shared by both AD and depression, which were screened by the Degree algorithm, MCC algorithm, and four machine learning algorithms. Two genes (ITGB5 and SPCS1) were confirmed as predictive biomarkers with AUC > 0.7. Furthermore, the nomogram indicated that ITGB5 and SPCS1 are good biomarkers in diagnosing AD with depression. Four drugs targeted at ITGB5 were determined by the DGIdb website. In conclusion, we identified two predictive biomarkers for AD with depression, thus providing promising therapeutic targets for AD with depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.