ArticleNature immunology2025
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation.
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Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
–field-weighted citation impact
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Who cites it
18 citing papers in PubMed.
- Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation.Cell proliferation · 2026Article
- Roles for specialized secretory epithelial cells in inflammatory bowel disease.Current opinion in gastroenterology · 2026Review
- Article
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- Rank-dependent control of tuft and BEST4 cell development in the intestine.Nature communications · 2026Article
- Review
- Review
- Article
- New-onset allergic diseases after SARS-CoV-2 infection: mechanistic hypotheses and emerging strategies for risk stratification.Frontiers in immunology · 2026Review
- Tuft cell-mediated pathogen sensing and inflammation resolution.Biochemical Society transactions · 2025Review
- Neuroepithelial VIP-VIPR1 interactions differentially control enteric type 1 and type 2 immunity.Nature immunology · 2025Article
- Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate.European journal of immunology · 2025Review
- New Perspectives on Classical Alarmin Responses to Intestinal Helminth Infection.Parasite immunology · 2025Review
- Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients.Nature communications · 2025Article
- ILC2 Diversity, Location, and Function in Pulmonary Disease.Immunological reviews · 2025Review
- Immunomodulatory biomaterials for treating chronic inflammation at mucosal sites.npj biomedical innovations · 2025Review
- The role of the tuft cell-interleukin-25 axis in the pathogenesis of inflammatory bowel disease.Frontiers in immunology · 2025Review
- A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity.Frontiers in immunology · 2025Article
Corrections and comments
- Update of
Authors and funding
20 authors.
Xiaogang Feng *Institute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-0343-1848
Tilde Andersson *Institute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-8168-5002
Pascal FlüchterInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-7279-3383
Julia GschwendInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7212-4393
Ivan BerestInstitute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-7607-9163
Julian L MuffInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-2032-7863
Antonie LechnerInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1636-3354
Aurelia GondrandInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0004-9989-4899
Patrick WestermannPrecision Proteomics Center, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID http://orcid.org/0000-0003-2894-6140
Nina BranderInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Daniele CarchidiInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Jeshua C De TenorioInstitute of Physiology, University of Zurich, Zurich, Switzerland.
Tianlang PanInstitute of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0009-0005-3425-6842
Ulrich BoehmExperimental Pharmacology, Center for Molecular Signaling (PZMS) and Center for Gender-Specific Biology and Medicine (CGBM), Saarland University, Homburg, Germany.
Christoph S N KloseDepartment of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-8803-2979
David ArtisJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1753-4100
Christoph B MessnerPrecision Proteomics Center, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Trese Leinders-ZufallCenter for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.ORCID http://orcid.org/0000-0002-0678-362X
Frank ZufallCenter for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.ORCID http://orcid.org/0000-0002-4383-8618
Christoph SchneiderInstitute of Physiology, University of Zurich, Zurich, Switzerland. christoph.schneider@uzh.ch.ORCID http://orcid.org/0000-0002-0452-2960
Funding
Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MMicrobiota-derived metabolites and the regulation of host immunity and inflammation (Diversity Supplement)R01AI172027 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI David Artis, Chun-Jun Guo · 2022 to 2026
$4.4MNeuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8MRegulation and function of innate lymphoid cells in the gutR01AI095466 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2011 to 2022
$3.7MNeuropeptide-mediated regulation of antihelminth immunityR01AI151599 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ARTIS, DAVID, SIRACUSA, MARK CHRISTOPHER · 2020 to 2024
$3.2MNeuro-immune regulation of intestinal inflammationR01DK126871 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2020 to 2024
$3.2MDietary Regulation of Intestinal Inflammation and RepairR01DK132244 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, GUO, CHUN-JUN · 2022 to 2025
$2.7MDeutsche Forschungsgemeinschaft (German Research Foundation) CRC/TRR 241 Project-ID 375876048Deutsche Forschungsgemeinschaft (German Research Foundation) FOR2599 Project-ID 22359157Deutsche Forschungsgemeinschaft (German Research Foundation) Sonderforschungsbereich-Transregio TRR 152Deutsche Forschungsgemeinschaft (German Research Foundation) SPP1937 - KL 2963/3-1 and KL 2963/2-1Deutsche Forschungsgemeinschaft (German Research Foundation) TRR 152NIAID NIH HHS R01 AI095466NIAID NIH HHS R01 AI151599NIAID NIH HHS R01 AI172027NIAID NIH HHS U01 AI095608NIAMS NIH HHS R01 AR070116NIDDK NIH HHS R01 DK126871NIDDK NIH HHS R01 DK132244Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 194216
Abstract
The tuft cell-group 2 innate lymphoid cell (ILC2) circuit orchestrates rapid type 2 responses upon detecting microbially derived succinate and luminal helminths. Our findings delineate key mechanistic steps involving IP3R2 engagement and Ca
Indexed as
Immunity, InnateInterleukin-17InterleukinsLymphocytesReceptors, Interleukin-17AnimalsHelminthiasisMiceMice, Inbred C57BLMice, KnockoutSuccinic AcidTuft CellsInterleukin-17InterleukinsMydgf protein, mouseReceptors, Interleukin-17Succinic Acid
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.