Evidence map›Paper›PMID 40075217›Full record

ArticleScientific reports2025

Association of serum adiponectin and leptin levels with inner retinal thickness among individuals with or without elevated HbA1c.

Neslihan D Koseoglu, Jiangxia Wang, Frederick Anokye-Danso, Jose Amezcua Moreno, Eumee Cha, Franklin Fuchs, Jacqueline Teed, Jianing Yao, Yan Zhang, Rexford S Ahima and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Neslihan D KoseogluRetina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jiangxia WangDepartment of Biostatistics, Johns Hopkins Biostatistics Center, Johns Hopkins University, Baltimore, MD, USA.
Frederick Anokye-DansoDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jose Amezcua MorenoRetina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eumee ChaRetina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Franklin FuchsBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Jacqueline TeedBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Jianing YaoDepartment of Biostatistics, Johns Hopkins Biostatistics Center, Johns Hopkins University, Baltimore, MD, USA.
Yan ZhangBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Rexford S AhimaDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mira M SachdevaRetina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. msachde4@jhmi.edu.

Funding

Adipose FHL1 in energy homeostasisR01DK136755 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$452k
Doris Duke Charitable Foundation 2020084Doris Duke Charitable Foundation Clinical Scientist Development AwardNIDDK NIH HHS R01 DK136755
6 · The paper itself

Abstract

Inner retinal thinning precedes clinical evidence of retinopathy in prediabetes and diabetes mellitus (DM), and may contribute to retinopathy development and progression. Serum levels of the adipokines leptin and adiponectin are inversely related in the setting of impaired glucose homeostasis, but their potential association with inner retinal thickness is unknown. In this prospective study, both eyes from 24 individuals with prediabetes or type 2 DM (glycated hemoglobin [HbA1c] ≥ 5.7) and 16 controls (HbA1c < 5.7) underwent spectral-domain optical coherence tomography imaging of the macula, and thickness of the nerve fiber layer (NFL) and ganglion cell layer-inner plexiform layer (GCL-IPL) was analyzed in each subfield of the Early Treatment Diabetic Retinopathy Study grid. Serum samples were collected and metabolic factors, including adiponectin and leptin, were measured. Adjusted regression analyses revealed inverse associations of these adipokines with NFL thickness that did not differ between prediabetes/DM and controls, but differential positive associations of adiponectin with GCL-IPL thickness only in the prediabetes/DM group. The results of our pilot study suggest opposing roles for adiponectin and leptin in the retina, similar to their relationship in systemic disease, and suggest that serum adiponectin may represent a potential clinical biomarker for inner retinal thickness in patients with elevated HbA1c.

Indexed as

AdiponectinDiabetes Mellitus, Type 2Diabetic RetinopathyGlycated HemoglobinLeptinRetinaAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPilot ProjectsPrediabetic StateProspective StudiesAdiponectinADIPOQ protein, humanGlycated Hemoglobinhemoglobin A1c protein, humanLeptin

Identifiers

PMID40075217
PMCPMC11904190

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.