Evidence map›Paper›PMID 40075261›Full record

ArticleMolecular medicine (Cambridge, Mass.)2025

Transposition element MERVL regulates DNA demethylation through TET3 in oxidative-damaged mouse preimplantation embryos.

Lihong Liu, Siyao Ha, Dan Cao, MingQing Li, Zhiling Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lihong LiuReproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, 515041, China.
Siyao HaInstitute Obsterics and Gynecology, Hospital of Obsterics and Gynecology,Fudan University, Shanghai, 200080, China.
Dan CaoReproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, 515041, China.
MingQing LiInstitute Obsterics and Gynecology, Hospital of Obsterics and Gynecology,Fudan University, Shanghai, 200080, China.
Zhiling LiReproductive Center, The First Affiliated Hospital of Shantou University Medical College, Shantou University, Shantou, 515041, China. stlizhiling@126.com.

Funding

Guangdong Provincial Science and Technology Project 2016A020218015National Natural Science Foundation of China 81471522National Natural Science Foundation of China 81871223Natural Science Foundation of Guangdong Province of China 2014A030313482
6 · The paper itself

Abstract

Transposable elements (TEs) comprise approximately half of eukaryotic genomes and significantly contribute to genome plasticity. In this study, we focused on a specific TE, MERVL, which exhibits particular expression during the 2-cell stage and commonly serves as an indicator of embryonic totipotency. However, its precise role in embryo development remains mysterious. We utilized DRUG-seq to investigate the effects of oxidative damage on genes and TEs expression. Our findings revealed that exposure to hydrogen peroxide (H

Indexed as

BlastocystDioxygenasesDNA DemethylationDNA MethylationDNA Transposable ElementsOxidative StressProto-Oncogene ProteinsAnimalsApoptosisDNA DamageEmbryonic DevelopmentFemaleGene Expression Regulation, DevelopmentalHydrogen PeroxideMiceDioxygenasesDNA Transposable ElementsHydrogen PeroxideProto-Oncogene ProteinsTet3 protein, mouseDNA methylationMERVLOxidative damageTET3

Identifiers

PMID40075261
PMCPMC11905524

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.