ArticleBMC gastroenterology2025
The association between the dietary index for gut microbiota and non-alcoholic fatty liver disease and liver fibrosis: evidence from NHANES 2017-2020.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.Hepatology communications · 2026Pooled it
- Adherence to the dietary index for gut microbiota and the 5-year incidence of metabolic dysfunction-associated steatotic liver disease in Iranian adults: a prospective cohort study.BMC gastroenterology · 2026Article
- Dietary index for gut microbiota and its protective role against osteoporosis: Evidence from NHANES 2007 to 2018.Medicine · 2026Article
- Joint Association of Diet Index for Gut Microbiota and MVPA With Central Obesity: The Mediating Role of Biological Age.Food science & nutrition · 2026Article
- Relationship Between Congestive Heart Failure and the Dietary Index of Gut Microbiota: Information From the National Health and Nutrition Examination Survey 2007-2018.Food science & nutrition · 2026Article
- Dietary Index for Gut Microbiota and Leisure Time Physical Activity: The Potential Combined Protective Impact on Hypertension Risk.Food science & nutrition · 2025Article
- Article
- Dietary index for gut microbiota and risk of incident irritable bowel syndrome: a large-scale prospective cohort study.Nutrition journal · 2025Article
- Are we standing on the shifting sands of post-transplant metabolic-associated steatotic liver disease?World journal of hepatology · 2025Review
- Gender-specific protective effects of dietary index for gut microbiota on cardiovascular disease: insights from NHANES 2007-2020.BMC cardiovascular disorders · 2025Article
- Interaction mechanism and intervention strategy between metabolic dysfunction-associated steatotic liver disease and intestinal microbiota.Frontiers in microbiology · 2025Review
- The dietary inflammation index and body mass index mediate the association between the dietary index for gut microbiota and sarcopenia in older women: evidence from NHANES 2011-2018.Frontiers in nutrition · 2025Article
- Association between the newly proposed dietary index for gut microbiota and thyroid function: NHANES 2007-2012.Frontiers in nutrition · 2025Article
- Association between a dietary index for gut microbiota and breast cancer history in adult women: findings from NHANES 2011-2020.Frontiers in nutrition · 2025Article
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6 authors.
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Abstract
backgroundImbalance in the gut microbiota is a key factor in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. The Dietary Index for Gut Microbiota (DI-GM) integrates the potential relationship between diet and gut microbiota diversity. This study aims to investigate the association between DI-GM and the risk of NAFLD and liver fibrosis, providing theoretical support for dietary intervention strategies.
methodsThis study utilized data from NHANES 2017-2020, including 6,181 eligible adult participants. The relationship between DI-GM and the risk of NAFLD and liver fibrosis was assessed using DI-GM quartiles, multivariate logistic regression, and restricted cubic spline (RCS) analysis. Subgroup analysis was performed to explore the predictive role of DI-GM in different populations. All analyses were weighted to ensure the representativeness of the results.
resultsDI-GM was negatively associated with the risks of NAFLD and liver fibrosis. As DI-GM scores increased, the risk of NAFLD and liver fibrosis significantly decreased (52.81%, 43.16%, 40.40%, and 31.98%, p < 0.05; 17.52%, 9.04%, 7.21%, and 6.78%, p < 0.05). Multivariate logistic regression analysis revealed that, in the unadjusted model (Model 1), for each unit increase in DI-GM, the risk of NAFLD decreased by 6.9% (OR = 0.931, 95% CI: 0.886-0.979, p < 0.001), while the risk of liver fibrosis decreased by 15.6% (OR = 0.844, 95% CI: 0.757-0.941, p < 0.05). In the quartile analysis, individuals in the highest DI-GM quartile (Q4) had a 58% lower risk of NAFLD compared to those in the lowest quartile (Q1) (OR = 0.42, 95% CI: 0.219-0.806, p < 0.001). The results remained significant even after adjusting for covariates. RCS analysis showed that DI-GM had a nonlinear relationship with the risks of NAFLD and liver fibrosis, with inflection points at scores of 2 and 5, indicating enhanced protective effects.
conclusionThis study reveals a negative association between DI-GM and the risk of NAFLD and liver fibrosis, highlighting the potential role of healthy dietary patterns in the prevention and management of NAFLD and liver fibrosis through gut microbiota modulation, providing a theoretical basis for dietary interventions.
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