ArticleInternational journal of molecular sciences2025
Identification of Prognostic Genes Related to Cell Senescence and Lipid Metabolism in Glioblastoma Based on Transcriptome and Single-Cell RNA-Seq Data.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics.Molecular cancer · 2025Review
- The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment.Theranostics · 2025Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma (GBM) is the most aggressive primary brain cancer, with poor prognosis due to its aggressive behavior and high heterogeneity. This study aimed to identify cellular senescence (CS) and lipid metabolism (LM)-related prognostic genes to improve GBM prognosis and treatment. Transcriptome and scRNA-seq data, CS-associated genes (CSAGs), and LM-related genes (LMRGs) were acquired from public databases. Prognostic genes were identified by intersecting CSAGs, LMRGs, and differentially expressed genes (DEGs), followed by WGCNA and univariate Cox regression. A risk model and nomogram were constructed. Analyses covered clinicopathological features, immune microenvironment, somatic mutations, and drug sensitivity. GBM scRNA-seq data identified key cells and prognostic gene expression. SOCS1 and PHB2 were identified as prognostic markers, contributing to the construction of a robust risk model with excellent predictive ability. High-risk group (HRG) patients had poorer survival, higher immune and stromal scores, and distinct somatic mutation profiles. Drug sensitivity analysis revealed significant differences in IC50 values. In microglia differentiation, SOCS1 and PHB2 showed dynamic expression patterns. These findings provide new strategies for GBM prognosis and treatment.
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Registered trials
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