Evidence map›Paper›PMID 40076609›Full record

ArticleInternational journal of molecular sciences2025

Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomics Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment.

Alisa B Nelson, Lyndsay E Reese, Elizabeth Rono, Eric D Queathem, Yinjie Qiu, Braedan M McCluskey, Alexandra Crampton, Eric Conniff, Katherine Cummins, Ella Boytim and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Alisa B NelsonDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Lyndsay E ReeseDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0003-1560-4886
Elizabeth RonoDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Eric D QueathemDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0001-7618-9554
Yinjie QiuMinnesota Supercomputing Institute, Minneapolis, MN 55455, USA.ORCID 0000-0002-0584-0688
Braedan M McCluskeyMinnesota Supercomputing Institute, Minneapolis, MN 55455, USA.ORCID 0000-0001-6423-7048
Alexandra CramptonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Eric ConniffDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Katherine CumminsDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-3803-4818
Ella BoytimMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Senali DansouDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Justin HwangMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1686-7103
Sandra E SafoDivision of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9593-4778
Patrycja PuchalskaDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
David K WoodDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-5225-2144
Kathryn L SchwertfegerDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Peter A CrawfordDivision of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-8597-4426

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1988 to 2005
$1.9M
TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · UNIVERSITY OF MINNESOTA TWIN CITIES · 1986 to 2025
$881k
Inclusive Excellence Training Program in the Systems Biology of Cardiovascular InflammationT32HL166142 · NHLBI · UNIVERSITY OF MINNESOTA · 2023 to 2025
$617k
Contributions of FGFR-Mediated Tumor-Stromal Interactions to Breast Cancer Growth and ProgressionR01CA215052 · UNIVERSITY OF MINNESOTA · 2025 to 2025
$378k
NCI NIH HHS R01 CA215052NCI NIH HHS R01CA215052NHLBI NIH HHS HL166142NHLBI NIH HHS T32 HL166142NIDDK NIH HHS R01 DK091538NIDDK NIH HHS R01DK091538NIDDK NIH HHS T32 DK007203NIDDK NIH HHS T32DK007203NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

Metabolic reprogramming is a hallmark of cancer, enabling tumor cells to adapt to and exploit their microenvironment for sustained growth. The liver is a common site of metastasis, but the interactions between tumor cells and hepatocytes remain poorly understood. In the context of liver metastasis, these interactions play a crucial role in promoting tumor survival and progression. This study leverages multiomics coverage of the microenvironment via liquid chromatography and high-resolution, high-mass-accuracy mass spectrometry-based untargeted metabolomics,

Indexed as

Colorectal NeoplasmsHepatocytesLiver NeoplasmsMetabolomicsTumor MicroenvironmentCell CommunicationCell Line, TumorCoculture TechniquesGlucoseHumansLiverMetabolomeMultiomicsGlucosecancer metabolismmetabolomicsmultiomicstumor microenvironment

Identifiers

PMID40076609
PMCPMC11900982

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.