Evidence map›Paper›PMID 40076762›Full record

ArticleInternational journal of molecular sciences2025

Arcyriaflavin A Alleviates Osteoporosis by Suppressing RANKL-Induced Osteoclastogenesis.

Mengbo Zhu, Mingwei Xu, Damien Bertheloot, Victoria C Brom, Alexander Sieberath, Jochen Salber, Kristian Welle, Christof Burger, Dieter C Wirtz, Shaowei Wang and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengbo ZhuDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.
Mingwei XuDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030013, China.
Damien BerthelootDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9495-706X
Victoria C BromDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.
Alexander SieberathDepartment of Experimental Surgery, Centre for Clinical Research, Ruhr-Universität Bochum, 44780 Bochum, Germany.ORCID 0000-0002-6676-4164
Jochen SalberDepartment of Experimental Surgery, Centre for Clinical Research, Ruhr-Universität Bochum, 44780 Bochum, Germany.ORCID 0000-0001-9738-2305
Kristian WelleDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-9340-9881
Christof BurgerDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-3431-4721
Dieter C WirtzDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-6189-5114
Shaowei WangDepartment of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030013, China.
Frank A SchildbergDepartment of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-0797-1945

Funding

China Scholarship Council (CSC) N/ADeutsche Forschungsgemeinschaft (DFG, German Research Foundation) EXC2151-390873048John Templeton Foundation #62214
6 · The paper itself

Abstract

Osteoclasts (OCs) are important therapeutic targets in the treatment of osteoporosis. The aim of this study was to explore a novel therapeutic approach for osteoporosis using Arcyriaflavin A (ArcyA), a natural compound derived from the marine invertebrate

Indexed as

OsteoclastsOsteogenesisOsteoporosisRANK LigandAnimalsBone ResorptionCell DifferentiationDisease Models, AnimalFemaleHumansMiceRANK LigandArcyriaflavin Amusculoskeletal immunologyosteoclastsosteoimmunologyosteoporosis

Identifiers

PMID40076762
PMCPMC11899857

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.